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Usage

Uses

Used in Organic Synthesis:
2-[(Diethylamino)methyl]-4-nitrophenol is used as a synthetic intermediate for the preparation of various organic compounds. Its presence in reactions can facilitate the formation of desired products through its reactivity and the influence it exerts on the reaction pathways. This makes it a versatile building block in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-[(Diethylamino)methyl]-4-nitrophenol is utilized as a key component in the synthesis of certain drugs. Its unique functional groups can be manipulated to create molecules with specific therapeutic properties, contributing to the development of new medications and treatments.
Used in Agrochemical Industry:
Similarly, in the agrochemical sector, 2-[(Diethylamino)methyl]-4-nitrophenol serves as a precursor in the synthesis of various agrochemicals. Its ability to be modified and incorporated into complex molecules makes it instrumental in the creation of pesticides, herbicides, and other agricultural products designed to protect crops and enhance yields.
Used in Specialty Chemicals:
2-[(Diethylamino)methyl]-4-nitrophenol also finds application in the production of specialty chemicals, which are often used in niche applications such as dyes, coatings, and advanced materials. Its versatility and reactivity make it a valuable component in the development of these high-value products.

Upstream product

• 2973-19-5 2-hydroxy-5-nitrobenzyl chloride 
• 109-89-7 diethylamine 
• 3299-38-5 4-(diethylamino)butan-2-one 
• 34461-00-2 nitromalondialdehyde sodium salt 
• 50-00-0 formaldehyd 
• 100-02-7 4-nitro-phenol 

Relevant academic research and scientific papers

The influence of steric and polar effects on hydrogen bonding in 2-(N,N-diethylamino)-methyl-4-NO2-phenols

Two crystal structures consisting of 2-(N,N-diethylamino)-methyl-4-NO2-phenol molecules were determined. In the triclinic crystals (with a = 9.527(2) A. b = 11.268(3) A c = 11.408(3) A, α = 87.80(3)°, β = 69.62(3)°, γ = 81.82(3)°, Z = 4, space group P1) asymmetric cyclic dimers were found, formed by two nonequivalent O-...H-N+ hydrogen bonds of 2.614(3) and 2.660(3) A lengths. In the complex of 2-(N,N-diethylamino)-methyl-4-NO2-phenol with 4-NO2-phenol (orthorhombic crystals with a = 20.732(4) A, b = 16.618(2) A, c = 10.452(2) A, Z = 8, space group Pbca) an intermolecular O-...H-O (2.525(2) A) hydrogen bond between 4-NO2-phenol and zwitterionic 2-(N,N-diethylamino)-methyl-4-NO2-phenol was found. In the latter molecule the intramolecular O-...-H-N+ (2.760(2) A) bridge is formed. The zwitterionic molecules form chains along the crystallographic b axis by NH+...O (3.105(2) A) hydrogen bridges. The N-H+ groups participate in bifurcated hydrogen bonds. The influence of the steric strain caused by N-alkyl chains and polar interactions of the NO2 group on the character of the hydrogen bond and the structure of cyclic dimers is discussed. The IR and UV spectra determined show the full agreement in description of the hydrogen bonding schemes, simultaneously demonstrating a drastic rearrangement of these schemes upon going to CCl4 solutions.

Cyclocondensation of nitromalonaldehyde sodium salt with substituted 1-amino-3-butanones

Cyclocondensation of nitromalonaldehyde sodium salt with substituted 1-amino-3-butanones afforded 2-dimethyl-, diethylaminomethyl-4-nitrophenols and 2-piperidylo-, morpholylomethyl-4-nitrophenols.

Preparation and NMR characterization of hydrogen bonding in 2- and 2,6-bis-(N,N-diethylaminomethyl)-4R-phenols

A series of Mannich mono- and di-bases derived from 4-substituted phenols were prepared and investigated by 1H and 13C NMR spectroscopy in chloroform-d1 solution.The chemical shifts of intramolecular hydrogen-bonded protons in Mannich bases depend on the