6554-28-5Relevant academic research and scientific papers
Acetylation of Nucleosides by N-Acetoxy-N-arylacetamides: Dependence on Base, Aryl Group, and Buffer Composition
Scribner, John D.,Scribner, Norma K.,Smith, David L.,Jenkins, Ellen,McCloskey, James A.
, p. 3143 - 3145 (1982)
Nucleosides treated with the carcinogen N,O-diacetyl-4-stilbenylhydroxylamine (1) in water and acetone are alkylated on the bases, and only alkylation products have been detected so far.In phosphate buffer at the same pH, adenosine and guanosine are acetylated on ribose, as determined by gas chromatography-mass spectrometry, in about the same yield as the total alkylation products.This acetylation does not take place in salt solution of the same pH and ionic strength.No alkylation or acetylation of adenosine or guanosine could be detected upon treatment with N,O-diacetyl-1-naphthylhydroxylamine (6), which solvolyzes at a rate comparable to that of 1, but cytidine was converted in low yield to N4-acetylcytidine.The results with 1 point out that apparently innocuous changes in medium may greatly alter the reactivity characteristics of some ultimate carcinogens, while the results with 6 indicate that steric hindrance in the ultimate carcinogen itself may completely alter its mechanism of decomposition from that expected.The biological consequences of these acylation reactions are unknown, although 6 has been tested for both mutagenic and carcinogenic activity and found inactive.
MONOMER FOR SYNTHESIS OF RNA, METHOD FOR PRODUCING SAME, AND METHOD FOR PRODUCING RNA
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Paragraph 0137, (2015/06/16)
The objective of the present invention is to provide a monomer for RNA synthesis which can be efficiently produced and therefore by which the producing cost of RNA can be remarkably decreased, and a method for efficiently producing the monomer in a small number of steps. In addition, the objective of the present invention is also to provide a method by which RNA can be efficiently produced even when a approximately stoichiometry amount of the monomer for RNA synthesis is used. The monomer for RNA synthesis according to the present invention is represented by the following formula (I) or (I'): wherein R1 is a protective group of the hydroxy group and R2 is an alkyl group or the like.
The action of adenosine deaminase (E.C. 3.5.4.4.) on adenosine and deoxyadenosine acetates: The crucial role of the 5'-hydroxy group for the enzyme activity
Ciuffreda, Pierangela,Casati, Silvana,Santaniello, Enzo
, p. 3239 - 3243 (2007/10/03)
From adenosine 1, 2'-deoxyadenosine 3 and 3'-deoxyadenosine 5 all the acetates were prepared by lipase-catalyzed reactions. Only the acetates with free 5'-hydroxy group were deaminated by adenosine deaminase (ADA), confirming the crucial role of 5'-OH for the enzyme activity. (C) 2000 Elsevier Science Ltd.
