65540-51-4Relevant academic research and scientific papers
Trifluoromethyl Sulfoxides: Reagents for Metal-Free C?H Trifluoromethylthiolation
Carlton, C. Grace,McDouall, Joseph J. W.,Perry, Gregory J. P.,Procter, David J.,Tayu, Masanori,Wang, Dong
, p. 15918 - 15922 (2020)
Trifluoromethyl sulfoxides are a new class of trifluoromethylthiolating reagent. The sulfoxides engage in metal-free C?H trifluoromethylthiolation with a range of (hetero)arenes. The method is also applicable to the functionalization of important compound classes, such as ligand derivatives and polyaromatics, and in the late-stage trifluoromethylthiolation of medicines and agrochemicals. The isolation and characterization of a sulfonium salt intermediate supports an interrupted Pummerer reaction mechanism.
An efficient and practical approach to trifluoromethylthiolation of α-haloketones/α-haloarylmethanes
Jiang, Min,Zhu, Fangxia,Xiang, Haoyue,Xu, Xing,Deng, Lianfu,Yang, Chunhao
, p. 6935 - 6939 (2015/06/25)
An efficient and practical approach to trifluoromethylthiolation of α-haloketones/α-haloarylmethanes was developed. The transformation employs only AgSCF3 and KI in situ generated active nucleophilic trifluoromethylthio species and cleanly occurs in up to quantitative yield at room temperature, thereby providing an unprecedentedly easy entry to various α-SCF3-substituted ketones/arylmethanes.
