65550-95-0

Basic information

• Product Name: N-benzyl-N'-(4-fluorophenyl)thiourea
• Synonyms: N-benzyl-N'-(4-fluorophenyl)thiourea;1-benzyl-3-(4-fluorophenyl)thiourea
• CAS NO: 65550-95-0
• Molecular Formula: C₁₄H₁₃FN₂S
• Molecular Weight: 260.3298232
• Mol File: 65550-95-0.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-benzyl-N'-(4-fluorophenyl)thiourea(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyl-N'-(4-fluorophenyl)thiourea(65550-95-0)
• EPA Substance Registry System: N-benzyl-N'-(4-fluorophenyl)thiourea(65550-95-0)

Safety Data

• Hazardous Substances Data: 65550-95-0(Hazardous Substances Data)

Upstream product

• 100-46-9 benzylamine 
• 371-40-4 4-fluoroaniline 
• 24075-34-1 4-fluorophenyl isocyanide 
• 1544-68-9 4-fluorophenyl isothiocyanate 

Relevant articles and documents

Chromatography-Free Multicomponent Synthesis of Thioureas Enabled by Aqueous Solution of Elemental Sulfur

The development of a new three-component chromatography-free reaction of isocyanides, amines and elemental sulfur allowed us the straightforward synthesis of thioureas in water. Considering a large pool of organic and inorganic bases, we first optimized the preparation of aqueous polysulfide solution from elemental sulfur. Using polysulfide solution, we were able to omit the otherwise mandatory chromatography, and to isolate the crystalline products directly from the reaction mixture by a simple filtration, retaining the sulfur in the solution phase. A wide range of thioureas synthesized in this way confirmed the reasonable substrate and functional group tolerance of our protocol.

Micelle-Enabled One-Pot Guanidine Synthesis in Water Directly from Isothiocyanate using Hypervalent Iodine(III) Reagents under Mild Conditions

In this work, we developed a one-pot synthesis of guanidine directly from isothiocyanate using DIB (diacetoxyiodobenzene) as a desulfurizing agent under micellar conditions in water. Our optimization study revealed that the use of 1 % TPGS-750-M as a surfactant with NaOH as an additive base at room temperature can convert a variety of isothiocyanates and amines into corresponding guanidines in excellent yields (69–95 %). This synthetic process in water can be applied to prepare guanidine at gram-scale quantity. Our aqueous micellar medium also demonstrated high reusability as the reaction can be performed for several cycles without losing its efficiency. The reaction is metal-free, utilizes water as solvent and practical (room temperature and open flask).

Ph3P/I2-mediated synthesis of N,N′,N″-substituted guanidines and 2-iminoimidazolin-4-ones from aryl isothiocyanates

A convenient one-pot procedure for the synthesis of acyclic and cyclic guanidines mediated by the Ph3P/I2 system is described. Sequential condensation of aryl isothiocyanates with amines followed by dehydrosulfurization and guanylation could lead to both symmetric and unsymmetric N,N′,N″-substituted derivatives. Through a tandem guanylation-cyclization, a series of 2-iminoimidazolin-4-ones could also be prepared in good yields from the reaction of aryl isothiocyanates with amino acid methyl esters.