65562-86-9Relevant academic research and scientific papers
Nickel-Catalyzed Alkylation of Ketone Enolates: Synthesis of Monoselective Linear Ketones
Das, Jagadish,Vellakkaran, Mari,Banerjee, Debasis
, p. 769 - 779 (2019)
Herein we have developed a Ni-catalyzed protocol for the synthesis of linear ketones. Aryl, alkyl, and heteroaryl ketones as well as alcohols yielded the monoselective ketones in up to 90% yield. The catalytic protocol was successfully applied in to a gram-scale synthesis. For a practical utility, applications of a steroid derivative, oleyl alcohol, and naproxen alcohol were employed. Preliminary catalytic investigations involving the isolation of a Ni intermediate and defined Ni-H species as well as a series of deuterium-labeling experiments were performed.
From selective transfer hydrogenation to selective hydrogen auto-transfer process: An efficient method for the synthesis of alkenyl ketones via iridium-catalyzed α-alkylation of ketones with alkenyl alcohols
Li, Feng,Li, Shun,Meng, Chong,Xu, Xiangchao,Yang, Chenchen,Yang, Jiazhi,Yu, Junjie
, p. 335 - 343 (2021/10/07)
A strategy for the synthesis of alkenyl ketones via the α-alkylation of ketones with alkenyl ketones has proposed and accomplished. In the presence of a metal–ligand bifunctional catalyst [Cp*Ir(2,2′-bpyO)(H2O)], a series of desirable products
A base-controlled chemoselective transfer hydrogenation of α,β-unsaturated ketones catalyzed by [IrCpCl2]2 with 2-propanol
Chen, Shu-Jie,Lu, Guo-Ping,Cai, Chun
, p. 13208 - 13211 (2015/03/05)
A simple homogeneous catalyst system based on commercially available [IrCpCl2]2 has been developed for the conjugate reduction of α,β-unsaturated ketones. Under the optimized conditions, a wide range of α,β-unsaturated ketones were reduced to saturated ketones in 83-98% yield. While switching the base from K2CO3 to KOH, saturated alcohols was selectively obtained.
