89044-55-3Relevant academic research and scientific papers
Reaction of α-Halogeno Ketones with Carbonyl Compounds Promoted by CeI3, CeCl3-NaI,or CeCl3-SnCl2
Fukuzawa, Shin-ichi,Tsuruta, Takuya,Fujinami, Tatsuo,Sakai, Shizuyoshi
, p. 1473 - 1478 (2007/10/02)
Reaction of α-halogeno ketones with aldehydes in the presence of CeI3 in tetrahydrofuran is found to give α,β-unsaturated ketones in excellent yields under mild conditions.In contrast, treatment of α-halogeno ketones and carbonyl compounds with CeCl3-NaI or CeCl3-SnCl2 affords β-hydroxy ketones in good yields.It is assumed that these reactions proceed via cerium enolates.The combined reagents, however, cannot be applied to a Reformatsky-type reaction.Regiospecific and aldehyde chemoselective aldol synthesis are also described.
Carbon-Carbon Bond Formation between α-Halogenoketones and Aldehydes Promoted by Cerium(III) Iodide or Cerium(III) Chloride-Sodium Iodide
Fukuzawa, Shin-ichi,Fujinami, Tatsuo,Sakai, Shizuyoshi
, p. 777 - 778 (2007/10/02)
α-Halogenoketones react with aldehydes to form α,β-unsaturated ketones accompanied by dehalogenation in the presence of cerium(III) iodide, but the use of cerium(III) chloride-sodium iodide results in the formation of β-keto alcohols.
