65568-08-3

Upstream product

• 108-73-6 3,5-dihydroxyphenol 
• 1891-11-8 (2,4-dimethoxyphenyl)acetonitrile 
• 6496-89-5 2,4-dimethoxyphenylacetic acid 

Downstream Products

• 853925-94-7 3-(2,4-dimethoxy-phenyl)-5,7-dihydroxy-4-oxo-4H-chromene-2-carboxylic acid ethyl ester 
• 88092-56-2 1-(2,4-Dimethoxy-phenyl)-2-(2,4,6-trihydroxy-phenyl)-ethane-1,2-dione 
• 61503-84-2 3-(2',4'-dimethoxyphenyl)-4-hydroxy-5,7-dimethoxy-2H-1-benzopyrane-2-one 
• 855627-35-9 5,7-diacetoxy-3-(2,4-dimethoxy-phenyl)-chromen-4-one 
• 54443-63-9 5,7-diacetoxy-3-(2,4-dimethoxy-phenyl)-chroman-4-one 
• 853925-95-8 3-(2,4-dimethoxy-phenyl)-5,7-dihydroxy-4-oxo-4H-chromene-2-carboxylic acid 
• 61243-75-2 2'-methoxybiochanin A 
• 38986-93-5 3-(2,4-dimethoxy-phenyl)-5,7-dihydroxy-2-methyl-chromen-4-one 
• 39604-69-8 1-(2'-hydroxy-4',6'-dimethoxyphenyl)-2-(2,4-dimethoxyphenyl)ethanone 
• 108974-66-9 3-(2,4-dimethoxy-phenyl)-4,5,7-trihydroxy-coumarin 
• 38987-07-4 5,7-diacetoxy-3-(2,4-dimethoxy-phenyl)-2-methyl-chromen-4-one 

Relevant academic research and scientific papers

Arylalkyl ketones, benzophenones, desoxybenzoins and chalcones inhibit TNF-α induced expression of ICAM-1: Structure-activity analysis

The interaction between leukocytes and the vascular endothelial cells (EC) via cellular adhesion molecules plays an important role in the pathogenesis of various inflammatory and autoimmune diseases. Small molecules that block these interactions have been targeted as potential therapeutic agents against acute and chronic inflammatory diseases. In an effort to identify potent intercellular cell adhesion molecule-1 (ICAM-1) inhibitors, a large number of arylalkyl ketones, benzophenones, desoxybenzoins and chalcones and their analogs (54 in total) have been synthesized and screened for their ICAM-1 inhibitory activity. The structure-activity relationship studies of these compounds identified three potent chalcone derivatives and also demonstrated the possible mechanism for their ICAM-1 inhibitory activities. The most active compound was found to be 79. A large number of arylalkyl ketones, benzophenones, desoxybenzoins and chalcones as well as their analogs (54 in total) were synthesized and screened for their ICAM-1 inhibitory activity. The structure-activity relationship studies of these compounds identified three potent chalcone derivatives and also demonstrated a possible mechanism of their ICAM-1 inhibitory activities. The most active compound was found to be 79. Copyright

PREPARATION METHOD OF 2-PHENYLACETOPHENONE DERIVATIVES

Disclosed is a preparation method of 2-phenylacetophenone derivatives which are used as key intermediates in total syntheses of coumestans and isoflavonoids such as coumestrol, genistein and daidzein which are phytoestrogens contained in soybean and black