65581-19-3

Usage

Uses

Used in Pharmaceutical Industry:
p-Aminobenzylchloride is used as a chemical intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents.
Used in Dye Industry:
p-Aminobenzylchloride is utilized as a precursor in the production of dyes, playing a crucial role in the creation of a wide range of colorants for various applications.
Used in Agrochemical Industry:
p-Aminobenzylchloride is employed as a building block in the synthesis of agrochemicals, aiding in the development of effective pesticides and other agricultural products.
Used in Organic Synthesis:
p-Aminobenzylchloride is used as a versatile reagent in organic synthesis, enabling the production of a variety of compounds, including amino acids, peptides, and heterocycles, which have diverse applications in research and industry.
It is essential to handle and store p-Aminobenzylchloride with care in a well-ventilated area and in an appropriate chemical storage container to minimize its hazardous effects on health and the environment.

Upstream product

• 100-14-1 4-nitrobenzyl chloride 

Downstream Products

• 156295-34-0 8-hydroxyquinoline-4-(N-p-chloromethylphenyl)sulphonamide 
• 1352080-35-3 7-(4-aminobenzyloxy)-4,5-dihydrotetrazolo[1,5-a]quinoline 
• 109735-98-0 4-Amino-thiobenzoesaeuredimethylamid 
• 1309581-24-5 C₃₅H₃₄ClN₅O₂ 

Relevant academic research and scientific papers

Unsaturated Mo in Mo4O4N3for efficient catalytic transfer hydrogenation of nitrobenzene using stoichiometric hydrazine hydrate

Transfer hydrogenation of nitroarenes to the corresponding anilines using hydrazine hydrate and non-noble metal catalysts has already been widely studied. However, the toxicity resulting from excess hydrazine hydrate and the high reaction temperature limit its industrial application. Herein, a novel N-doped molybdenum oxide compound (Mo4O4N3) was in situ prepared from g-C3N4 and (NH4)6Mo7O24·4H2O (AHM). The as-prepared Mo4O4N3 can achieve a 99% yield of aniline using a stoichiometric molar ratio of hydrazine hydrate (-NO2?:?N2H4·H2O = 1?:?1.5) at room temperature for 50 minutes. Mechanistic experiments and characterization techniques indicate that the acidic sites of unsaturated Mo in Mo4O4N3 can efficiently activate N2H4 molecules to form active hydrogen species for catalytic transfer hydrogenation of nitroarenes without the generation of hazardous NH3. Besides, Mo4O4N3 still exhibited excellent catalytic performance for the large-scale reaction without solvent. This work may offer a feasible and efficient strategy for arylamine production. This journal is

TARGETED PEPTIDE CONJUGATES

The present invention relates to the preparation and use of therapeutic compounds for the treatment of diseases at specific subcellular target areas such as specific cellular organelles. In particular, the therapeutic compounds of the invention are specific for modifying enzyme activity within targeted organelles or structures of cells and tissues. Subcellular organelles and structures that may be specifically targeted by compounds of the present invention include lysosomes, autophagasomes, the endoplasmic reticulum, the Golgi complex, peroxisomes, the nucleus, membranes and the mitochondria.

Preparation and characterization of Fe3O4/SiO2/CdS nanocomposites as efficient magnetic photocatalysts for the reduction of nitro compounds under visible LED irradiation

A series of magnetic Fe3O4/SiO2/CdS nanocomposites were synthesized through a facile and convenient method. The characterization of the prepared nanocomposites was performed by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy dispersive X-ray (EDX), vibrating sample magnetometer (VSM), UV–Vis spectroscopy, and UV–vis diffuse reflectance spectroscopy (DRS). The prepared magnetic photocatalysts were first utilized for the photocatalytic reduction of nitro compounds under visible LED irradiation. The Fe3O4/SiO2/CdS nanocomposites exhibited enhanced photoactivity compared with the bare CdS and commercial CdS (Aldrich). The results demonstrated that Fe3O4/SiO2/CdS nanocomposites have potential to provide a promising visible light driven photocatalyst for the selective reduction of nitro compounds to corresponding amines under mild conditions. The prepared photocatalyst can be recovered by magnetic separation and successfully reused for 3 cycles.

Distinctive size effects of Pt nanoparticles immobilized on Fe3O4@PPy used as an efficient recyclable catalyst for benzylic alcohol aerobic oxidation and hydrogenation reduction of nitroaromatics

Fe3O4@PPy composite microspheres have been synthesized using Fe3O4 microspheres as a chemical template in an ultrasonic treatment process. Pt nanoparticles (NPs) were immobilized on Fe3O4@PPy by using ethylene glycol (EG) and NaBH4 as reducing agents. The information on the morphologies, sizes, and dispersion of Pt NPs of the as-prepared catalysts was verified by TEM, XRD, FTIR and XPS. As expected, the chemical reduction methods remarkably affected the size of Pt NPs (～2.5 nm and ～5.5 nm) and the prepared catalysts exhibited high catalytic activities as well as awesome stabilities for aerobic oxidation of benzylic alcohols and hydrogenation reduction of nitroaromatics. It was highlighted that size effects for the catalytic properties of the two reactions were found to be quite different. Fe3O4@PPy-Pt (2.5 nm) afforded a higher conversion for benzylic alcohol aerobic oxidation, while the selectivities toward benzaldehyde over these two catalysts were similar. However, they showed almost the same catalytic performance for hydrogenation reduction of a majority of nitroaromatics. What is more, Fe3O4@PPy-Pt (5.5 nm) gave better activities than several nitroaromatics, which were relatively difficult to be hydrotreated under the same conditions. In addition, the EG reduced Fe3O4@PPy-Pt catalyst exhibited slightly poorer stability than the NaBH4 reduced Fe3O4@PPy-Pt catalyst in the recycle tests, which might be due to the agglomeration of small Pt NPs.

Highly efficient and chemoselective transfer hydrogenation of nitroarenes at room temperature over magnetically separable Fe-Ni bimetallic nanoparticles

A highly chemoselective catalytic transfer hydrogenation (CTH) of nitroarenes to corresponding amino derivatives is achieved with Fe-Ni bimetallic nanoparticles (Fe-Ni NP's) as the catalyst and NaBH4 at room temperature. Their catalytic efficiency is ascribed to the presence of Ni sites on the bimetallic surface that not only hinder the surface corrosion of the iron sites but also facilitate efficient electron flow from the catalyst surface to the adsorbed nitro compounds. This facet is corroborated with reusability studies as well as surface characterization of the catalyst before and after its repetitive usage. Thus, these nanoparticles efficiently catalyze the reduction of functionalized nitroarenes to corresponding amines without use of corrosive agents like base or other additives under ambient conditions and are easily separated by a laboratory magnet in an eco-friendly manner.

Efficient reduction of nitroarenes to the corresponding anilines with sulfur in basic media under solvent-free conditions

Aromatic nitro compounds can be conveniently reduced to the corresponding primary amines in the presence of S8 under solvent-free conditions in excellent yields. Alumina supported NaOH catalyses this transformation. Chemoselectivity was observed in the reduction of the nitro group in the presence of phenol, carboxylic acid, aldehyde, and benzyl halide groups.

Montmorillonite catalyzed reduction of nitroarenes with hydrazine

Aromatic nitro compounds were readily reduced to the corresponding amino compounds in good yields with montmorillonite(K-10) and hydrazine.

Effect of Meta and Para Substituents on the Stannous Chloride Reduction of Nitrobenzenes in Aqueous Ethanol

The rate of reduction of 24 meta- and para-substituted nitrobenzenes with SnCl2 catalyzed by HCl in ethanol-water (90 : 10 v/v) at 30 degC has been measured iodometrically.The rate is expressed as υ = kst0.5, suggesting that the sole active reducing species is SnCl3- and the dissociation of HCl is very small.The effect of meta and para substituents in which the solvation of the substituent is taken into account was examined with the Hammett equation, which gave a ρ value of 2.1 +/- 0.1.Yukawa-Tsuno and Taft equations, in which resonance and inductive effects are separated, are also discussed.