65581-19-3

Basic information

• Product Name: p-Aminobenzylchloride
• Synonyms: p-Aminobenzylchloride;4-(chloroMethyl)aniline;Benzenamine,4-(chloromethyl)-
• CAS NO: 65581-19-3
• Molecular Formula: C₇H₈ClN
• Molecular Weight: 141.03
• Mol File: 65581-19-3.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 257.6 °C at 760 mmHg
• Flash Point: 109.6 °C
• Appearance: /
• Density: 1.185 g/cm³
• PKA: 4.28±0.10(Predicted)
• CAS DataBase Reference: p-Aminobenzylchloride(CAS DataBase Reference)
• NIST Chemistry Reference: p-Aminobenzylchloride(65581-19-3)
• EPA Substance Registry System: p-Aminobenzylchloride(65581-19-3)

Safety Data

• Hazardous Substances Data: 65581-19-3(Hazardous Substances Data)

Usage

General Description

p-Aminobenzylchloride, also known as 4-chloro-α-methylaniline, is an organic compound with the chemical formula C7H8ClN. It is a derivative of aniline and has a benzyl group attached to the amino group. p-Aminobenzylchloride is commonly used in organic synthesis as a chemical intermediate for the production of various pharmaceuticals, dyes, and agrochemicals. It is a versatile building block in the synthesis of a variety of compounds, including amino acids, peptides, and heterocycles. The compound is a pale yellow to brown liquid with a strong, pungent odor and is classified as a hazardous chemical due to its potential to cause skin and eye irritation, as well as respiratory and central nervous system effects. It should be handled and stored with care in a well-ventilated area and in an appropriate chemical storage container.

Upstream product

• 100-14-1 4-nitrobenzyl chloride 

Downstream Products

• 109735-98-0 4-Amino-thiobenzoesaeuredimethylamid 
• 1309581-24-5 C₃₅H₃₄ClN₅O₂ 
• 1352080-35-3 7-(4-aminobenzyloxy)-4,5-dihydrotetrazolo[1,5-a]quinoline 
• 156295-34-0 8-hydroxyquinoline-4-(N-p-chloromethylphenyl)sulphonamide 

Relevant articles and documents

Unsaturated Mo in Mo4O4N3for efficient catalytic transfer hydrogenation of nitrobenzene using stoichiometric hydrazine hydrate

Transfer hydrogenation of nitroarenes to the corresponding anilines using hydrazine hydrate and non-noble metal catalysts has already been widely studied. However, the toxicity resulting from excess hydrazine hydrate and the high reaction temperature limit its industrial application. Herein, a novel N-doped molybdenum oxide compound (Mo4O4N3) was in situ prepared from g-C3N4 and (NH4)6Mo7O24·4H2O (AHM). The as-prepared Mo4O4N3 can achieve a 99% yield of aniline using a stoichiometric molar ratio of hydrazine hydrate (-NO2?:?N2H4·H2O = 1?:?1.5) at room temperature for 50 minutes. Mechanistic experiments and characterization techniques indicate that the acidic sites of unsaturated Mo in Mo4O4N3 can efficiently activate N2H4 molecules to form active hydrogen species for catalytic transfer hydrogenation of nitroarenes without the generation of hazardous NH3. Besides, Mo4O4N3 still exhibited excellent catalytic performance for the large-scale reaction without solvent. This work may offer a feasible and efficient strategy for arylamine production. This journal is

Preparation and characterization of Fe3O4/SiO2/CdS nanocomposites as efficient magnetic photocatalysts for the reduction of nitro compounds under visible LED irradiation

A series of magnetic Fe3O4/SiO2/CdS nanocomposites were synthesized through a facile and convenient method. The characterization of the prepared nanocomposites was performed by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy dispersive X-ray (EDX), vibrating sample magnetometer (VSM), UV–Vis spectroscopy, and UV–vis diffuse reflectance spectroscopy (DRS). The prepared magnetic photocatalysts were first utilized for the photocatalytic reduction of nitro compounds under visible LED irradiation. The Fe3O4/SiO2/CdS nanocomposites exhibited enhanced photoactivity compared with the bare CdS and commercial CdS (Aldrich). The results demonstrated that Fe3O4/SiO2/CdS nanocomposites have potential to provide a promising visible light driven photocatalyst for the selective reduction of nitro compounds to corresponding amines under mild conditions. The prepared photocatalyst can be recovered by magnetic separation and successfully reused for 3 cycles.

Highly efficient and chemoselective transfer hydrogenation of nitroarenes at room temperature over magnetically separable Fe-Ni bimetallic nanoparticles

A highly chemoselective catalytic transfer hydrogenation (CTH) of nitroarenes to corresponding amino derivatives is achieved with Fe-Ni bimetallic nanoparticles (Fe-Ni NP's) as the catalyst and NaBH4 at room temperature. Their catalytic efficiency is ascribed to the presence of Ni sites on the bimetallic surface that not only hinder the surface corrosion of the iron sites but also facilitate efficient electron flow from the catalyst surface to the adsorbed nitro compounds. This facet is corroborated with reusability studies as well as surface characterization of the catalyst before and after its repetitive usage. Thus, these nanoparticles efficiently catalyze the reduction of functionalized nitroarenes to corresponding amines without use of corrosive agents like base or other additives under ambient conditions and are easily separated by a laboratory magnet in an eco-friendly manner.