65581-30-8

Upstream product

• 65581-29-5 (S)-6-Benzyloxycarbonylamino-3-tert-butoxycarbonylamino-hexanoic acid methyl ester 
• 189188-67-8 ((S)-4-tert-Butoxycarbonylamino-6-diazo-5-oxo-hexyl)-carbamic acid benzyl ester 
• 186581-53-3 diazomethane 
• 2480-93-5 Boc-Orn(Z)-OH 
• 233689-91-3 (S)-5-(benzyloxycarbonylamino)-2-(tert-butoxycarbonylamino)pentylmethanesulfonate 

Downstream Products

• 928850-93-5 4-[(S)-6-benzyloxycarbonylamino-3-tert-butoxycarbonylaminohexanoyl]-piperazine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester 
• 911218-82-1 benzyl ((1S,7S,12S)-7,12-bis[(tert-butoxycarbonyl)amino]-1-{3-[(tert-butoxycarbonyl)amino]propyl}-19,19-dimethyl-2,9,17-trioxo-18-oxa-3,10,16-triazaicos-1-yl)carbamate 
• 881837-35-0 Benzyl {(4S)-6-({(2S)-2,5-bis[(tert-butoxycarbonyl)amino]pentyl}amino)-4-[(tert-butoxycarbonyl)amino]-6-oxohexyl}carbamate 

Relevant academic research and scientific papers

COMPOUND HAVING READ-THROUGH ACTIVITY

[Problem] Provision of a novel compound having read-through activity and a drug for the treatment of nonsense mutation-type disease containing this compound. [Solution] A compound represented by the following general formula (1): and a pharmaceutical composition containing this compound.

Peptidyl β-homo-aspartals: Specific inhibitors of interleukin-1β converting enzyme and its homologues (caspases)

Inhibition of interleukin-1β convening enzyme (ICE), apopain, papain, thrombin and trypsin with substrate like peptidyl L- and D-α-aldehydes and their L-β-homo-aldehyde analogues was investigated. The L-β-homo-aspartals appear to be specific inhibitors fo