65614-75-7

Upstream product

• 3637-01-2 3,4-dimethylacetophenone 
• 36799-48-1 3,4-dimethylphenylglyoxylic acid 
• 108-88-3 toluene 
• 95-47-6 o-xylene 
• 103-80-0 phenylacetyl chloride 
• 108-38-3 m-xylene 

Downstream Products

• 59411-15-3 1-(3,4-dimethylphenyl)-2-phenylethane-1,2-dione 
• 1416727-67-7 N-(1-(3,4-dimethylphenyl)-2-phenylethyl)-4-methoxyaniline 
• 1416727-88-2 N-(1-(3,4-dimethylphenyl)-2-phenylethylidene)-4-methoxyaniline 
• 112948-89-7 3',4'-Dimethyl-2-benzyl-benzophenon 
• 65614-87-1 2,4,5-Triphenyl-3,6-dimethyl-1-(3',4-dimethylphenyl)-benzol 
• 65614-94-0 1,2-dimethyl-4-(2-phenylethynyl)benzene 
• 75628-40-9 1-(3,4-Dimethyl-phenyl)-5-(2-methoxy-naphthalen-1-yl)-2,3-diphenyl-pentane-1,5-dione 

Relevant academic research and scientific papers

Ruthenium(II)-Catalyzed Cross-Coupling of Benzoyl Formic Acids with Toluenes: Synthesis of 2-Phenylacetophenones

Herein, we report a direct method to synthesize 2-phenylacetophenone through a ruthenium(II)-catalyzed cross-coupling reaction between acyl and benzyl radical. The various derivatives of 2-phenylacetophenone were prepared easily in moderate to good yields. These reactions provide a straightforward pathway to synthesize a variety of ketones bearing various functional groups.

A Facile One-Pot Synthesis of Vicinal Di- and Triketones from α-Methylene Ketones by NBS-DMSO Oxidation

The reaction of 1,2-diarylethanones (1a-u) with N-bromosuccinimide in anhydrous dimethyl sulphoxide afforded diarylethanediones (2a-u) in excellent yields.Under similar conditions, 1-phenyl-2-butanone (3) gave 1-phenyl-1,2-butanedione (4) in fair yield in addition to a small amount of 1-phenyl-3-methylthio-1,2-butanedione (5) and 1-phenyl-1-methylthio-2-butanone (6). 4-Phenyl-2-butanone (7), 1,3-diphenyl-2-propanone (9), and 1,3-diphenyl-1,3-propanedione (10) gave the corresponding triketones monohydrate (8) and (11). 1-Indanone (12), 2-indanone (13), and 1,3-indandione (14) gave ninhydrin (15) in good yields.In the case of 3-phenyl-1-indanone (16), 3-phenyl-2-bromo-1-indanone (17), 3-phenyl-2-bromo-1-indenone (18) and 3-phenyl-1-indenone (19) were obtained. 1-Phenyl-1-propanone (20) and 1-phenyl-1-butanone (22) gave the corresponding α-(methylthio)ketones (21) and (22). 1,3,3-Triphenylpropanone (24a) and 1-phenyl-3-methyl-1-butanone (24b) yielded only the corresponding α-bromoketones (25a,b) in good yields.These α-bromoketones, however, afforded the corresponding α-diketones (26a,b) in moderate yields when α-bromoketones reacted with dimethyl sulphoxide in the presence of AgBF4.