65655-82-5Relevant academic research and scientific papers
A catalysis study of mesoporous MCM-41 supported Schiff base and CuSO4·5H2O in a highly regioselective synthesis of 4-thiazolidinone derivatives from cyclocondensation of mercaptoacetic acid
Pang, Hai-Xia,Hui, Yong-Hai,Fan, Kui,Xing, Xue-Jian,Wu, Yang,Yang, Jing-Hui,Shi, Wei,Xie, Zheng-Feng
, p. 335 - 339 (2016/03/16)
Mesoporous MCM-41 supported Schiff base and CuSO4·5H2O shows high catalytic activity in the cyclocondensation of mercaptoacetic acid with imines (or aldehydes and amines) to afford pharmaceutically important thiazolidinone derivatives. The catalytic reactions involving two-components or three-components afforded the desired product in high yields (up to 98% and 99%). Moreover, the catalyst works well with respect to recyclability, giving the product in 85% and 83% yields after recycling six times.
Carbodiimide mediated synthesis of 4-thiazolidinones by one-pot three-component condensation
Srivastava, Tumul,Haq,Katti
, p. 7619 - 7624 (2007/10/03)
In the present study, 4-thiazolidinones have been assembled by DCC mediated three-component reaction of amine, aldehyde and mercaptoacetic acid. The final compounds are obtained in quantitative yields within one hour.
