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TYRPHOSTIN AG 1024, also known as AG-1024, is a selective and potent inhibitor of the insulin-like growth factor 1 receptor (IGF-1R). It functions by antagonizing the binding of insulin-like growth factor 1 (IGF-1) to its receptor, thereby disrupting the signaling pathways that promote cell growth, transformation, and survival. This makes AG-1024 a valuable compound in the study and potential treatment of cancer.
Used in Pharmaceutical Industry:
TYRPHOSTIN AG 1024 is used as an anticancer agent for its ability to inhibit the proliferation of cancer cells and induce apoptosis. It targets the IGF-1R, which is often overexpressed in various types of cancer, and plays a crucial role in tumor growth and resistance to apoptosis. By inhibiting the IGF-1R, AG-1024 can potentially reduce the tumorigenic potential of cancer cells and increase their susceptibility to cell death.
TYRPHOSTIN AG 1024 is also used as a research tool for studying the role of the IGF-1R in cellular processes. Its selective inhibition of IGF-1R autophosphorylation and the subsequent effects on the PI3K/Akt signaling pathway make it a valuable compound for investigating the mechanisms of cell growth, transformation, and survival in the context of cancer development and progression.

65678-07-1

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65678-07-1 Usage

references

[1] párrizas m1, gazit a, levitzki a, wertheimer e, leroith d. specific inhibition of insulin-like growth factor-1 and insulin receptor tyrosine kinase activity and biological function by tyrphostins. endocrinology. 1997 apr;138(4):1427-33.[2] fan p1, agboke fa1, mcdaniel re1, sweeney ee1, zou x1, creswell k1, jordan vc2.inhibition of c-src blocks oestrogen-induced apoptosis and restores oestrogen-stimulated growth in long-term oestrogen-deprived breast cancer cells. eur j cancer. 2014 jan; 50(2):457-68.

Check Digit Verification of cas no

The CAS Registry Mumber 65678-07-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,5,6,7 and 8 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 65678-07:
(7*6)+(6*5)+(5*6)+(4*7)+(3*8)+(2*0)+(1*7)=161
161 % 10 = 1
So 65678-07-1 is a valid CAS Registry Number.
InChI:InChI=1/C14H13BrN2O/c1-14(2,3)11-5-9(4-10(7-16)8-17)6-12(15)13(11)18/h4-6,18H,1-3H3

65678-07-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-[(3-bromo-5-tert-butyl-4-hydroxyphenyl)methylidene]propanedinitrile

1.2 Other means of identification

Product number -
Other names 3-Bromo-5-t-butyl-4-hydroxy-benzylidenemalonitrile

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:65678-07-1 SDS

65678-07-1Downstream Products

65678-07-1Relevant academic research and scientific papers

Compositions for killing internal parasites containing 3-tert-alkyl-4-hydroxy-5-halo-benzylidene-malonitriles

-

, (2008/06/13)

A compound of the general formula I STR1 wherein R1 is halogen, R4 is a highly branched alkyl group, R2 and R3 which may be the same or different are hydrogen or halogen atoms or lower alkyl groups.

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