100643-27-4

Basic information

• Product Name: 4-Pyrimidinol, 2,6-diamino- (9CI)
• Synonyms: 4-Pyrimidinol, 2,6-diamino- (9CI);2,4-diaMino-6(1H)-pyriMidone
• CAS NO: 100643-27-4
• Molecular Formula: C₄H₆N₄O
• Molecular Weight: 126.11664
• Product Categories: PYRIMIDINE;Pyrimidines
• Mol File: 100643-27-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 288.5 °C at 760 mmHg
• Flash Point: 128.3 °C
• Appearance: /
• Density: 1.84 g/cm³
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 10.85±0.10(Predicted)
• CAS DataBase Reference: 4-Pyrimidinol, 2,6-diamino- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Pyrimidinol, 2,6-diamino- (9CI)(100643-27-4)
• EPA Substance Registry System: 4-Pyrimidinol, 2,6-diamino- (9CI)(100643-27-4)

Safety Data

• Hazardous Substances Data: 100643-27-4(Hazardous Substances Data)

Usage

Description

4-Pyrimidinol, 2,6-diamino(9CI) is a heterocyclic chemical compound with the molecular formula C4H6N4O. It is a derivative of pyrimidinol, featuring a pyrimidine ring structure with two nitrogen and one oxygen atom, along with two amino groups and a hydroxyl group attached to the ring. 4-Pyrimidinol, 2,6-diamino(9CI) holds potential in the pharmaceutical industry for the development of innovative drugs and therapies, making it a significant subject for research and exploration in medicinal chemistry.

Uses

Used in Pharmaceutical Industry:
4-Pyrimidinol, 2,6-diamino(9CI) is used as a key intermediate in the synthesis of various pharmaceutical compounds for [application reason]. Its unique chemical structure and properties allow it to be a versatile building block in the creation of new drugs and therapies.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 4-Pyrimidinol, 2,6-diamino(9CI) is utilized as a subject of study for understanding its chemical properties and exploring its potential applications in drug development. Its structure makes it a promising candidate for further research to enhance the discovery of novel therapeutic agents.

Upstream product

• 18852-51-2 sodium cyanoacetic acid ethyl ester 
• 113-00-8 guanidine nitrate 
• 105-56-6 ethyl 2-cyanoacetate 
• 124-41-4 sodium methylate 
• 506-93-4 guanidine nitrate 
• 105-34-0 methyl 2-cyanoacetate 
• 50-01-1 guanidine hydrochloride 
• 55034-35-0 cyanoacetyl-guanidine 

Downstream Products

• 96716-37-9 2-amino-6-methyl-7-phenyl-3H-pyrido[2,3-d]pyrimidin-4-one 
• 40769-83-3 2-amino-6-nitro-3H-pyrido[2,3-d]pyrimidin-4-one 
• 22288-77-3 2,5-diaminothiazolo<4,5-d>pyrimidin-7(6H)-one 
• 95769-03-2 2-amino-7-phenyl-3H-pyrido[2,3-d]pyrimidin-4-one 
• 156-83-2 6-chloro-pyrimidine-2,4-diyldiamine 
• 6312-72-7 5-bromo-2,6-diamino-4(3H)-pyrimidinone 
• 62981-82-2 2-amino-6-methyl-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidine 

Relevant articles and documents

Green Microwave-assisted Multicomponent Route to the Formation of 5,8-Dihydropyrido[2,3-d]pyrimidine Skeleton in Aqueous Media

Three-component synthesis of 5-substituted 6-acetyl-2-amino-7-methyl-5,8-dihydropyrido[2,3-d]pyrimidines was brought to facile energy-efficient and environmental-friendly conditions using multicomponent reaction, microwave field as an activation method and hot water as a solvent. A series of the target compounds was synthesized using the developed procedure.

Preparation methods of 2,4-diamido-5-nitroso-6-hydroxypyridine and guanine

The invention discloses a preparation method of 2,4-diamido-5-nitroso-6-hydroxypyridine. The preparation method comprises the following steps: (1) in a sodium methoxide methanol solution, carrying outa ring-closure reaction between methyl cyanoacetate and guanidine salt; (2) adding recycled absolute methanol to be diluted, filtering and recycling byproduct sodium nitrate; (3) concentrating a filter liquor, and recycling absolute methanol; (4) adding water to destroy excessive sodium methoxide, concentrating and recycling water-containing methyl alcohol; (5) in a diluted methane acid solution,carrying out a nitrosation reaction among an obtained concentrate, sodium nitrite and a nitrosation mother liquor; (6) after the reaction ends, carrying out cooling crystallization, filtering, takinga filter liquor as the nitrosation mother liquor to be used indiscriminately, and drying an obtained filter cake to obtain the 2,4-diamido-5-nitroso-6-hydroxypyridine. According to the preparation method, indiscriminate use of the nitrosation mother liquor and recycling of sodium nitrate and methyl alcohol are realized, and simultaneously the diluted methane acid solution is used for replacing concentrated sulfuric acid used, in the prior art, to carry out the nitrosation reaction, so that the recycling of a solvent and a reagent is facilitated, and the displacement of waste water is reduced.