65691-08-9Relevant academic research and scientific papers
Oxidative acylation of α,α-diarylallylic alcohols: Synthesis of 1,2,4-triarylbutane-1,4-diones
Li, Yong,Leng, Yuting,Wang, Shiwei,Gao, Yuhui,Lv, Huiyan,Chang, Junbiao,Wu, Yusheng,Wu, Yangjie
, (2018)
A metal-free mediated oxidative acylation of α,α-diarylallylic alcohols with simple aromatic aldehydes for the synthesis of 1,2,4-triphenylbutane-1,4-diones is presented. In the presence of TBPB (tert-butyl peroxybenzoate), desired products were obtained in good to excellent yields for 28 examples. This protocol features high regioselectivity, wide functional group tolerance and atom economy.
1,4-dicarbonyl compound and preparation method thereof
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Paragraph 0025; 0026, (2017/08/31)
The invention provides a 1,4-dicarbonyl compound and a preparation method thereof. The preparation method comprises the following steps: (1) adding alpha,alpha-diaryl allyl alcohol, aromatic formaldehyde, TBPB (tert-butyl peroxybenzoate) and methylbenzene into a Schlenk tube, and reacting for 20 to 28 hours at the temperature of 100 to 140 DEG C under an air condition so as to obtain a reaction product; and (2) washing the reaction product in the step (1) with a saturated NaCl solution, then carrying out extraction by using ethyl acetate, carrying out reduced pressure distillation to remove a solvent to obtain a crude product, carrying out thin-layer chromatography separation on the crude product by using petroleum ether and ethyl acetate as developers so as to obtain the 1,4-dicarbonyl compound. The innovation point lies in that addition rearrangement acylation on olefinic bonds is directly realized through a C-H bond direct functionalization method in allyl alcohol creatively, so that a synthetic method for synthesizing the 1,4-dicarbonyl compound is created.
Catalytic asymmetric hydrogenation of 2,3,5-trisubstituted pyrroles
Kuwano, Ryoichi,Kashiwabara, Manabu,Ohsumi, Masato,Kusano, Hiroki
, p. 808 - 809 (2008/09/20)
Catalytic asymmetric hydrogenation of N-Boc-protected pyrroles proceeded with high enantioselectivity by using a ruthenium catalyst modified with a trans-chelating chiral bisphosphine PhTRAP. The ruthenium catalyst prepared from Ru(η3-methallyl
