65709-33-3

Usage

Uses

Used in Pharmaceutical Research:
4-FPP is utilized as a research compound for the development of new treatments for various psychiatric and neurological disorders. Its psychoactive properties and effects on the central nervous system make it a valuable candidate for studying the underlying mechanisms of mood regulation and cognitive function.
Used in Controlled Substances Regulation:
Due to its potential for abuse and dependence, 4-FPP is considered a controlled substance in some countries. It is used as a reference point for regulatory measures aimed at preventing the misuse and distribution of psychoactive substances with similar effects.
Used in Forensic Toxicology:
4-FPP is employed as a target analyte in forensic toxicology for the detection and identification of substances in biological samples. Its presence in samples can provide valuable information for legal and medical investigations related to substance abuse and intoxication cases.
Used in Drug Synthesis:
4-FPP serves as a key intermediate in the synthesis of other psychoactive compounds and pharmaceuticals. Its unique chemical structure and properties make it a valuable building block for the development of novel therapeutic agents with potential applications in various medical fields.

InChI:InChI=1/C10H13FN2/c11-9-3-1-8(2-4-9)10-7-12-5-6-13-10/h1-4,10,12-13H,5-7H2/p+2/t10-/m0/s1

Upstream product

• 403-32-7 (4-fluorophenyl)glyoxal 
• 107-15-3 ethylenediamine 
• 939975-25-4 2-(4-fluorophenyl)pyrazine 
• 712-40-3 3-(4-fluorophenyl)-5,6-dihydropyrazin-2(1H)-one 
• 32222-45-0 4-fluoromandelic acid 
• 7550-03-0 ethyl 2-(4-fluorophenyl)-2-hydroxyacetate 
• 1813-94-1 ethyl 4-fluorobenzoylformate 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 1421005-03-9 C₂₄H₂₅FN₂ 

Downstream Products

• 137665-56-6 (RS)-7-fluoro-8-[3-(4-fluorophenyl)-1-piperazinyl]-1-methyl-4-oxo-1,4-dihydrobenzo[b ][1,8]naphthyridine-3-carboxylic acid 
• 1130983-27-5 1-[3-(4-fluoro-phenyl)-piperazin-1-yl]-6,7-dimethoxy-isoquinoline-4-carbonitrile 
• 612507-29-6 2S-(4-fluorophenyl)-piperazine 

Relevant academic research and scientific papers

Discovery of novel 2-(3-phenylpiperazin-1-yl)-pyrimidin-4-ones as glycogen synthase kinase-3β inhibitors

We herein describe the results of further evolution of glycogen synthase kinase (GSK)-3β inhibitors from our promising compounds containing a 2-phenylmorpholine moiety. Transformation of the morpholine moiety into a piperazine moiety resulted in potent GSK-3β inhibitors. SAR studies focused on the phenyl moiety revealed that a 4-fluoro-2-methoxy group afforded potent inhibitory activity toward GSK-3β. Based on docking studies, new hydrogen bonding between the nitrogen atom of the piperazine moiety and the oxygen atom of the main chain of Gln185 has been indicated, which may contribute to increased activity compared with that of the corresponding phenylmorpholine analogues. Effect of the stereochemistry of the phenylpiperazine moiety is also discussed.

Silicon Amine Reagents for the Photocatalytic Synthesis of Piperazines from Aldehydes and Ketones

Silicon amine protocol (SLAP) reagents for photocatalytic cross-coupling with aldehydes and ketones to form N-unprotected piperazines have been developed. This blue light promoted process tolerates a wide range of heteroaromatic, aromatic, and aliphatic aldehydes and structurally and stereochemically complex SLAP reagents. It provides a tin-free alternative to SnAP (tin amine protocol) reagents for the synthesis of substituted piperazines.

Piperazine derivatives and the use thereof as medicament

The present inventions relate to substituted piperazine derivatives of general formula (I) and to the manufacture of said compounds, pharmaceutical compositions comprising a compound according to general formula (I), and the use of said compounds for the treatment of various medical conditions related to glycine transporter-1 (GlyT1).

PIPERAZINE DERIVATIVES AND THE USE THEREOF AS MEDICAMENT

The present inventions relate to substituted piperazine derivatives of general formula (I) and to the manufacture of said compounds, pharmaceutical compositions comprising a compound according to general formula (I), and the use of said compounds for the treatment of various medical conditions related to glycine transporter-1 (GlyT1).

A simple one-pot method for the mercuric oxide mediated synthesis of piperazines via oxidative diamination of olefins

Mercuric oxide mediated one-pot synthesis of substituted piperazines via oxidative diamination of olefins with N-protected ethylene diamine has been reported. Among the various conditions tried, mercuric(II)oxide/tetrafluoroboric acid gave good to excellent yields of the desired products. A series of piperazines have been synthesized and characterized by NMR and mass spectroscopy methods.

SUBSTITUTED BIS ARYL AND HETEROARYL COMPOUNDS AS SELECTIVE 5HT2A ANTAGONISTS

The present invention relates to a series of substituted bis aryl and heteroaryl compounds of formula (I): Wherein X, Y, Z, A, B, D, Ar, R 1 and R2 are as defined herein. The compounds of this invention are selective 5HT2A antagonists, and are therefore, useful in treating a variety of diseases including but not limited to a wide variety of sleep disorders as disclosed and claimed herein.

2-Arylpiperazine derivatives and the preparation thereof

A process is provided for preparing 2-arylpiperazine derivatives and more particularly, 2-phenylpiperazine derivatives of the formula STR1 wherein R represents a group selected from the group consisting of a halogen atom, a lower alkyl group (having carbon atoms of 1 to about 8, preferably 1 to 4), a lower alkoxy group (having carbon atoms of 1 to about 8, preferably 1 to 4), a nitro group, a cyano group, a benzyloxy group, a hydroxy group and when n is 2 R is a methylenedioxy group, and n represents 1, 2 or 3.