65709-33-3

Basic information

• Product Name: 2-(4-FLUORO-PHENYL)-PIPERAZINE
• Synonyms: 2-(4-FLUORO-PHENYL)-PIPERAZINE;2-(4-Fluorophenyl)piperazine95%
• CAS NO: 65709-33-3
• Molecular Formula: C₁₀H₁₃FN₂
• Molecular Weight: 180.22
• Product Categories: pharmacetical;API intermediates
• Mol File: 65709-33-3.mol
• Article Data: 7

Chemical Properties

• Melting Point: 111-114°C
• Boiling Point: 287.2 °C at 760 mmHg
• Flash Point: 127.5 °C
• Appearance: /
• Density: 1.079 g/cm³
• Vapor Pressure: 0.00252mmHg at 25°C
• Storage Temp.: 2-8°C
• PKA: 8.76±0.40(Predicted)
• CAS DataBase Reference: 2-(4-FLUORO-PHENYL)-PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-FLUORO-PHENYL)-PIPERAZINE(65709-33-3)
• EPA Substance Registry System: 2-(4-FLUORO-PHENYL)-PIPERAZINE(65709-33-3)

Safety Data

• Hazardous Substances Data: 65709-33-3(Hazardous Substances Data)

Usage

General Description

2-(4-Fluoro-phenyl)-piperazine, also known as 4-fluorophenylpiperazine (4-FPP), is a psychoactive chemical that belongs to the class of piperazine derivatives. It is a derivative of piperazine and contains a fluorine atom attached to the phenyl ring. 4-FPP has been found to have a stimulant effect on the central nervous system and has been reported to produce euphoria, increased energy, and enhanced mood in individuals. It has also been researched for its potential as a treatment for various psychiatric and neurological disorders. However, its recreational use has also been reported, and it is considered a controlled substance in some countries due to its potential for abuse and dependence.

InChI:InChI=1/C10H13FN2/c11-9-3-1-8(2-4-9)10-7-12-5-6-13-10/h1-4,10,12-13H,5-7H2/p+2/t10-/m0/s1

Upstream product

• 460-00-4 1-Bromo-4-fluorobenzene 
• 1813-94-1 ethyl 4-fluorobenzoylformate 
• 7550-03-0 ethyl 2-(4-fluorophenyl)-2-hydroxyacetate 
• 32222-45-0 4-fluoromandelic acid 
• 712-40-3 3-(4-fluorophenyl)-5,6-dihydropyrazin-2(1H)-one 
• 1421005-03-9 C₂₄H₂₅FN₂ 
• 403-32-7 (4-fluorophenyl)glyoxal 
• 107-15-3 ethylenediamine 
• 939975-25-4 2-(4-fluorophenyl)pyrazine 

Downstream Products

• 612507-29-6 2S-(4-fluorophenyl)-piperazine 
• 1130983-27-5 1-[3-(4-fluoro-phenyl)-piperazin-1-yl]-6,7-dimethoxy-isoquinoline-4-carbonitrile 
• 137665-56-6 (RS)-7-fluoro-8-[3-(4-fluorophenyl)-1-piperazinyl]-1-methyl-4-oxo-1,4-dihydrobenzo[b ][1,8]naphthyridine-3-carboxylic acid 

Relevant articles and documents

Discovery of novel 2-(3-phenylpiperazin-1-yl)-pyrimidin-4-ones as glycogen synthase kinase-3β inhibitors

We herein describe the results of further evolution of glycogen synthase kinase (GSK)-3β inhibitors from our promising compounds containing a 2-phenylmorpholine moiety. Transformation of the morpholine moiety into a piperazine moiety resulted in potent GSK-3β inhibitors. SAR studies focused on the phenyl moiety revealed that a 4-fluoro-2-methoxy group afforded potent inhibitory activity toward GSK-3β. Based on docking studies, new hydrogen bonding between the nitrogen atom of the piperazine moiety and the oxygen atom of the main chain of Gln185 has been indicated, which may contribute to increased activity compared with that of the corresponding phenylmorpholine analogues. Effect of the stereochemistry of the phenylpiperazine moiety is also discussed.

Piperazine derivatives and the use thereof as medicament

The present inventions relate to substituted piperazine derivatives of general formula (I) and to the manufacture of said compounds, pharmaceutical compositions comprising a compound according to general formula (I), and the use of said compounds for the treatment of various medical conditions related to glycine transporter-1 (GlyT1).

A simple one-pot method for the mercuric oxide mediated synthesis of piperazines via oxidative diamination of olefins

Mercuric oxide mediated one-pot synthesis of substituted piperazines via oxidative diamination of olefins with N-protected ethylene diamine has been reported. Among the various conditions tried, mercuric(II)oxide/tetrafluoroboric acid gave good to excellent yields of the desired products. A series of piperazines have been synthesized and characterized by NMR and mass spectroscopy methods.