65739-28-8

Upstream product

• 1132-44-1 1-acetyl-3-phenylthiourea 
• 874-60-2 4-methyl-benzoyl chloride 
• 16794-68-6 4-methylbenzoyl isothiocyanate 
• 62-53-3 aniline 
• 99-94-5 p-Toluic acid 
• 1147550-11-5 ammonium thiocyanate 

Downstream Products

• 65739-35-7 4-methyl-N-(3-phenyl-[1,3]thiazetidin-2-ylidene)-benzamide 
• 99-75-2 4-methyl-benzoic acid methyl ester 
• 103-85-5 monophenylthiourea 
• 1000998-71-9 2-[(Z)-4-methylbenzoylimino]-4-oxo-3-phenyl-3,4-dihydro[1,3]thiazine-6-carboxylic acid methyl ester 
• 1000998-65-1 4'-methyl-N-[4-oxo-3-phenyl-3,4-dihydro[1,3]thiazin-(2Z)-ylidene]benzamide 
• 1402043-89-3 (Z)-methyl-2-[(Z)-2-(4-methylbenzoylimino)-4-oxo-3-phenyl-1,3-thiazolidin-5-ylidene]acetate 
• 133476-53-6 4-Methyl-N-[1-morpholin-4-yl-1-phenylamino-meth-(Z)-ylidene]-benzamide 
• 133476-52-5 4-Methyl-N-[1-phenylamino-1-piperidin-1-yl-meth-(Z)-ylidene]-benzamide 
• 133476-51-4 N,N-Dimethyl-N'-(4-methyl-benzoyl)-N''-phenyl-guanidine 

Relevant academic research and scientific papers

NOVEL THIOUREA OR UREA DERIVATIVE, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING AIDS, CONTAINING SAME AS ACTIVE INGREDIENT

Disclosed are novel thiourea or urea derivatives inhibitory of HIV activity. Also provided are a method for preparing the thiourea or urea derivatives, and a pharmaceutical composition for the prophylaxis or therapy of AIDS comprising the derivatives. Hav

NOVEL THIOUREA OR UREA DERIVATIVE, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING AIDS, CONTAINING SAME AS ACTIVE INGREDIENT

Disclosed are novel thiourea or urea derivatives inhibitory of HIV activity. Also provided are a method for preparing the thiourea or urea derivatives, and a pharmaceutical composition for the prophylaxis or therapy of AIDS comprising the derivatives. Hav

Synthesis and crystal structure of some novel 2-aroylimino-3-aryl-4-phenyl- 1,3-thiazolines

An efficient synthesis of some novel 2-aroylimino-3-aryl-4-phenyl-1,3- thiazolines was carried out by base-catalyzed cyclization of 1-aroyl-3-arylthioureas with acetophenone in the presence of bromine. The structures were confirmed by spectroscopic data,

Synthesis and bioactivity of some new 1-tolyl-3-aryl-4-methylimidazole-2- thiones

Three series of new 1-(isomeric methyl)benzoyl-3-arylthioureas (1-3a-i) were prepared from 2-, 3-, and 4-methylbenzoyl chlorides via isothiocyanate formation followed by treatment with various substituted anilines. The base-catalyzed condensation of thiou

Synthesis of benzoyl-N-phenylthioureas under microwave irradiation and phase transfer catalysis conditions

A simple, rapid and efficient method for the synthesis of benzoyl-N-phenylthioureas under microwave irradiation is reported. The effect of microwave irradiation power, times and phase transfer catalyst on the reaction is investigated.

Aroylthioureas: New organic ionophores for heavy-metal ion selective electrodes

Thiourea derivatives (46 aroylthioureas) having different substituents close to the sulfur atom were synthesized and their ionophore potential in ion selective electrodes (ISEs) was examined. Structural considerations were taken into account based on the corresponding heavy-metal ISE parameters. As ionophores, some 1-furoyl-3-substitnted thioureas (series 2) gave the best results in Pb(II), Hg(II) and Cd(II) ISEs. The strong intramolecular hydrogen bond in series 2 allows ligand interaction only through the C=S group. Substituents on the furan and phenyl rings give rise to low solubility in the membrane plasticizer. 3-Alkyl substituted furoylthioureas improve solubility but enhance oxidative processes with chain length. New X-ray diffraction (XRD) structures and theoretical DFT calculations were considered in the analysis of the substituent influence on the selectivity of ISEs. These new ionophores have advantages because of their stability, simple synthesis and easy modification of the sulfur binding ability resulting from substitution.

THE METHANOLYSIS KINETICS AND DISSOCIATION CONSTANTS OF 1-(SUBST. BENZOYL)-3-PHENYLTHIOUREAS

A series of seven 1-(subst. benzoyl)-phenylthioureas have been prepared and their dissociation constants and solvolysis rate constant have been measured in methanol at 25 deg C.The reaction constant found show that the solvolysis rate is limited by the attack of methoxide ion on the benzoyl carbonyl group of the non-dissociated substrate.The polar effect of substituents in benzoyl group is extensively transferred also by the intramolecular hydrogen bond.

INVESTIGATIONS IN THE SERIES OF ACYLTHIOUREAS. ACIDITY IN DIMETHYLFORMAMIDE

The pKa values of three series of substituted 1-furoyl- and 1-benzoyl-3-arylthioureas were determined in dimethylformamide.It was shown that the investigated acylthioureas are more acidic than pyridine-substituted thioureas and substituted thio