657401-67-7 Usage
Uses
Used in Pharmaceutical Research:
2-(4-TERT-BUTOXYCARBONYLAMINOPIPERIDINE-1-CARBONYL)PYRROLIDINE-1-CARBOXYLIC ACID BENZYL ESTER is used as a key intermediate in the synthesis of novel drug molecules, leveraging its complex molecular structure and functional groups to contribute to the development of new therapeutic agents.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 2-(4-TERT-BUTOXYCARBONYLAMINOPIPERIDINE-1-CARBONYL)PYRROLIDINE-1-CARBOXYLIC ACID BENZYL ESTER serves as a structural component in the design and synthesis of potential pharmaceuticals, taking advantage of its unique features to enhance drug efficacy and selectivity.
Used in Drug Development:
2-(4-TERT-BUTOXYCARBONYLAMINOPIPERIDINE-1-CARBONYL)PYRROLIDINE-1-CARBOXYLIC ACID BENZYL ESTER is utilized in drug development processes to create new chemical entities with potential therapeutic applications, capitalizing on its versatility and reactivity in organic synthesis to improve drug candidates' pharmacokinetic and pharmacodynamic profiles.
Used in Organic Synthesis:
As a building block in organic synthesis, 2-(4-TERT-BUTOXYCARBONYLAMINOPIPERIDINE-1-CARBONYL)PYRROLIDINE-1-CARBOXYLIC ACID BENZYL ESTER is employed to construct a variety of complex organic molecules, including those with potential applications in material science, agrochemicals, and other specialty chemical industries. Its presence of multiple functional groups allows for versatile synthetic routes and the creation of diverse molecular architectures.
Check Digit Verification of cas no
The CAS Registry Mumber 657401-67-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,5,7,4,0 and 1 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 657401-67:
(8*6)+(7*5)+(6*7)+(5*4)+(4*0)+(3*1)+(2*6)+(1*7)=167
167 % 10 = 7
So 657401-67-7 is a valid CAS Registry Number.
657401-67-7Relevant articles and documents
Synthesis of new glycyrrhetinic acid (GA) derivatives and their effects on tyrosinase activity
Um, Soo-Jong,Park, Myoung-Soon,Park, Si-Ho,Han, Hye-Sook,Kwon, Youn-Ja,Sin, Hong-Sig
, p. 5345 - 5352 (2003)
To synthesize glycyrrhetinic acid (GA) derivatives (3, 4, 5, 10, 13, 14, 15, and 16), we first removed the ketonic group in the C-11 position, and the carboxylic function at the C-30 position was kept intact, reduced to an alcohol, or transformed to an aldehyde corresponding derivatives 10 and 13. Glycyrrhetinic acid (GA) derivatives (3, 4, 5, 15, and 16) were coupled with 4-amino piperpyridine derivatives (12 and 14) and 4-fluorobenzyl bromide at C-30 carboxylic acid position of glycyrrhetinic acid. In subsequent tyrosinase assays, we found that GA derivatives 4, 5, and 16 were not active at early time points, but strongly inhibited tyrosinase activity at late time points. Of the GA derivatives examined, derivative 5 was most active, with an IC50 value of 50 μM after 2 h reaction. IC50 values of derivatives 4 and 16 were 120 and 170 μM, respectively. Further kinetic data indicated that these derivatives are slow-binding inhibitors of tyrosinase. The time-dependent inhibition was reversed when vitamin C or kojic acid was used, that is, both compounds showed active inhibition at early time points. These results suggest that GA derivatives are much more stable than vitamin C or kojic acid, although their intrinsic inhibitory potentials are relatively low. Higher stability and activity suggest that GA derivative 5 might be a useful candidate for skin whitening. copy; 2003 Published by Elsevier Ltd.
