6575-25-3

Basic information

• Product Name: Benzene, 1,3-dichloro-2-ethynyl-
• Synonyms: Benzene, 1,3-dichloro-2-ethynyl-;1,3-Dichloro-2-ethynyl-benzene
• CAS NO: 6575-25-3
• Molecular Formula: C₈H₄Cl₂
• Molecular Weight: 171
• Mol File: 6575-25-3.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzene, 1,3-dichloro-2-ethynyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1,3-dichloro-2-ethynyl-(6575-25-3)
• EPA Substance Registry System: Benzene, 1,3-dichloro-2-ethynyl-(6575-25-3)

Safety Data

• Hazardous Substances Data: 6575-25-3(Hazardous Substances Data)

Usage

General Description

Benzene, 1,3-dichloro-2-ethynyl- is a chemical compound that is also known by the name 1,3-dichloro-2-ethynylbenzene. It is a colorless liquid with a sweet, pleasant odor. Benzene, 1,3-dichloro-2-ethynyl- is primarily used in the synthesis of pharmaceuticals and agrochemicals. It is also used as an intermediate in the production of dyes, pigments, and other industrial chemicals. 1,3-dichloro-2-ethynylbenzene is considered to be a hazardous chemical and should be handled with care due to its potential to cause skin and eye irritation, as well as respiratory issues if inhaled. It is important to use proper protective equipment and follow safety protocols when working with this compound.

Upstream product

• 558-13-4 carbon tetrabromide 
• 83-38-5 2,6-dichlorobenzaldehyde 
• 19230-28-5 1,3-dichloro-2-iodobenzene 
• 133280-47-4 2,6-dichlorophenyl trifluoromethanesulphonate 
• 87-65-0 2,6-Dichlorophenol 
• 74-86-2 acetylene 
• 24653-82-5 1,1-diacetoxy-1-(2,6-dichlorophenyl)methane 
• 20595-49-7 (2E)-3-(2,6-dichlorophenyl)prop-2-enoic acid 
• 19393-92-1 1-bromo-2,6-dichlorobenzene 
• 24653-87-0 2,3-dibromo-3-(2,6-dichloro-phenyl)-propionic acid 

Downstream Products

• 1255533-04-0 1-(2,6-dichlorophenylethynyl)-8-iodonaphthalene 
• 1190707-75-5 2-chloro-6-(2,6-dichlorophenyl)-7H-pyrrolo[2,3-d]pyrimidine 
• 1190707-74-4 7-tert-butyl-2-chloro-6-(2,6-dichlorophenyl)-7H-pyrrolo[2,3-d]pyrimidine 
• 1190707-76-6 tert-butyl 2-((2-chloro-6-(2,6-dichlorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl)thiomorpholine-4-carboxylate 
• 1190707-10-8 6-(2,6-dichlorophenyl)-N-(3,4-difluorobenzyl)-7-(thiomorpholin-2-ylmethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine 
• 1300038-54-3 C₂₉H₂₉Cl₂F₂N₅O₂S 
• 2008-58-4 2,6-dichlorobenzamide 
• 1253949-68-6 1-(2-chlorophenyl)-2-(2,6-dichlorophenyl)ethyne 
• 1422960-18-6 5,6-bis[(2,6-dichlorophenyl)ethynyl]-1,2-dihydroacenaphthylene 

Relevant articles and documents

Three-coordinate copper(II) alkynyl complex in C-C bond formation: The sesquicentennial of the glaser coupling

Copper(II) alkynyl species are proposed as key intermediates in numerous Cu-catalyzed C-C coupling reactions. Supported by a β-diketiminate ligand, the three-coordinate copper(II) alkynyl [CuII]-C≡CAr (Ar = 2,6-Cl2C6H3) forms upon reaction of the alkyne H-C≡CAr with the copper(II) tertbutoxide complex [CuII]-OtBu. In solution, this [CuII]-C≡CAr species cleanly transforms to the Glaser coupling product ArC≡C-C≡CAr and [CuI](solvent). Addition of nucleophiles R′C≡C-Li (R′ = aryl, silyl) and Ph-Li to [CuII]-C≡CAr affords the corresponding Csp-Csp and Csp-Csp2 coupled products RC≡C-C≡CAr and Ph-C≡CAr with concomitant generation of [CuI](solvent) and {[CuI]-C≡CAr}-, respectively. Supported by density functional theory (DFT) calculations, redox disproportionation forms [CuIII](C≡CAr)(R) species that reductively eliminate R-C≡CAr products. [CuII]-C≡CAr also captures the trityl radical Ph3C· to give Ph3C-C≡CAr. Radical capture represents the key Csp-Csp3 bond-forming step in the copper-catalyzed C-H functionalization of benzylic substrates R-H with alkynes H-C≡CR′ (R′ = (hetero)aryl, silyl) that provide Csp-Csp3 coupled products R-C≡CR via radical relay with tBuOOtBu as oxidant.

HORMONE RECEPTOR MODULATORS FOR TREATING METABOLIC MUTAGENIC AND FIBROTIC CONDITIONS AND DISORDERS

The invention relates to activators of FXR useful in the treatment of autoimmune disorders, liver disease, intestinal disease, kidney disease, cancer, and other diseases in which FXR plays a role, having the Formula (I): wherein L1, A, X1

The Dual Role of 1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU) in the Synthesis of Terminal Aryl- and Styryl-Acetylenes via Umpolung Reactivity

The dual role of the bicyclic amidine base 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) was demonstrated in a synthesis of terminal aryl- and styryl-acetylenes. Mechanistically, a tandem process involving elimination/Umpolung/protonation occurs in a single step to generate terminal aryl- and styryl-acetylenes from geminal dibromoalkenes. The key to the success of this transformation lies in the organobase-mediated generation of the acetylide from the 1-bromoalkynes at room temperature. The unique characteristics of DBU as an inherently safer reagent make it an attractive alternative to previous systems wherein required pyrophoric reagents and nonambient temperatures remain unsolved issues. The procedure does not work for the synthesis of alkyl-acetylenes.