Benzene, 1,3-dichloro-2-ethynyl-

Base Information

• Chemical Name: Benzene, 1,3-dichloro-2-ethynyl-
• CAS No.: 6575-25-3
• Molecular Formula: C8H4Cl2
• Molecular Weight: 171.026
• Mol file: 6575-25-3.mol

Synonyms:1,3-Dichloro-2-ethynyl-benzene;BENZENE,1,3-DICHLORO-2-ETHYNYL-;Benzene, 1,3-dichloro-2-ethynyl-;2-Aethinyl-1,3-dichlor-benzol;2-ethynyl-1,3-dichloro-benzene;1,3-dichloro-2-ethynylbenzene;2,6-dichlorophenylacetylene;2,6-dichloroethynylbenzene;2,6-dichlorophenylethyne;

Chemical Property of Benzene, 1,3-dichloro-2-ethynyl-

Chemical Property:

• PSA: 0.00000
• LogP: 2.97470

Purity/Quality:

97% ^*data from raw suppliers

1,3-dichloro-2-ethynylbenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzene, 1,3-dichloro-2-ethynyl-

There total 13 articles about Benzene, 1,3-dichloro-2-ethynyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

β,β-dibromo-2,6-dichlorostyrene → 1,3-dichloro-2-ethynyl-benzene (6575-25-3)

Guidance literature:

β,β-dibromo-2,6-dichlorostyrene; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1.5h;

With ammonium chloride; In tetrahydrofuran;

Reference yield: 85.0%

carbon tetrabromide (558-13-4) + 2,6-dichlorobenzaldehyde (83-38-5) → 1,3-dichloro-2-ethynyl-benzene (6575-25-3)

Guidance literature:

carbon tetrabromide; 2,6-dichlorobenzaldehyde; With triisopropyl phosphite; In acetonitrile; at 0 ℃; for 0.166667h;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium hydroxide; In acetonitrile; at 0 - 20 ℃; for 4h;

DOI:10.1002/adsc.201801334

Reference yield: 57.0%

[(2,6-dichlorophenyl)ethynyl]trimethylsilane → 1,3-dichloro-2-ethynyl-benzene (6575-25-3)

Guidance literature:

With potassium carbonate; In methanol; at 20 ℃;

upstream raw materials:

2,3-dibromo-3-(2,6-dichloro-phenyl)-propionic acid

1-bromo-2,6-dichlorobenzene

(2E)-3-(2,6-dichlorophenyl)prop-2-enoic acid

1,1-diacetoxy-1-(2,6-dichlorophenyl)methane

Downstream raw materials:

5-(2,6-dichlorophenyl)-3-(3-nitrophenyl)isoxazole

1,3-dichloro-2-(chloroethynyl)benzene

2,6-dichlorobenzamide

2-chloro-6-(2,6-dichlorophenyl)-7H-pyrrolo[2,3-d]pyrimidine