65756-82-3

Upstream product

• 100-52-7 benzaldehyde 
• 106-65-0 Dimethyl succinate 
• 67-56-1 methanol 
• 65756-81-2 (Z)-2-benzylidenesuccinic acid 
• 23055-10-9 1,4-dimethyl but-2-enedioate 
• 624-48-6 dimethyl cis-but-2-ene-1,4-dioate 
• 95453-89-7 dimethyl 2-(diphenoxyphosphonyl)succinate 
• 92466-70-1 bis(2,2,2-trifluoroethyl)phosphite 

Downstream Products

• 65756-81-2 (Z)-2-benzylidenesuccinic acid 
• 56426-36-9 dimethyl 5-phenyl-1H-pyrazole-3,4-dicarboxylate 
• 167313-90-8 methyl (2E,3Z)-3-carbamoyl-4-phenyl-2-(3,4,5-trimethoxybenzylidene)-but-3-enoate 
• 534599-20-7 (R)-4-oxo-1,2,3,4-tetrahydronaphthalen-2-ylmetyl 4-methylbenzenesulfonate 
• 534599-19-4 (S)-4-oxo-1,2,3,4-tetrahydronaphthalen-2-ylmetyl 4-methylbenzenesulfonate 
• 534599-18-3 (R)-(-)-3-hydroxymethyl-1,2,3,4-tetrahydronaphthalen-1-one 
• 130272-52-5 dimethyl (R)-(+)-benzylsuccinate 
• 113867-23-5 (R)-4-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid 
• 108062-78-8 4-oxo-1,2,3,4-tetrahydronaphthalen-2-ylmetyl 4-methylbenzenesulfonate 
• 21307-97-1 (R)-2-benzylsuccinic acid 
• 3972-36-9 (2S)-benzylsuccinic acid 
• 36092-42-9 2-benzylsuccinic acid 
• 6566-40-1 4-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid 
• 35262-43-2 dimethyl 2-benzylsuccinate 

Relevant academic research and scientific papers

Inactive pseudoenzyme subunits in heterotetrameric BbsCD, a novel short-chain alcohol dehydrogenase involved in anaerobic toluene degradation

Anaerobic toluene degradation proceeds by fumarate addition to produce (R)-benzylsuccinate as first intermediate, which is further degraded via β-oxidation by five enzymes encoded in the conserved bbs operon. This study characterizes two enzymes of this pathway, (E)-benzylidenesuccinyl-CoA hydratase (BbsH), and (S,R)-2-(α-hydroxybenzyl)succinyl-CoA dehydrogenase (BbsCD) from Thauera?aromatica. BbsH, a member of the enoyl-CoA hydratase family, converts (E)-benzylidenesuccinyl-CoA to 2-(α-hydroxybenzyl)succinyl-CoA and was subsequently used in a coupled enzyme assay with BbsCD, which belongs to the short-chain dehydrogenases/reductase (SDR) family. The BbsCD crystal structure shows a C2-symmetric heterotetramer consisting of BbsC2 and BbsD2 dimers. BbsD subunits are catalytically active and capable of binding NAD+ and substrate, whereas BbsC subunits represent built-in pseudoenzyme moieties lacking all motifs of the SDR family required for substrate binding or catalysis. Molecular modeling studies predict that the active site of BbsD is specific for conversion of the (S,R)-diastereomer of 2-(α-hydroxybenzyl)succinyl-CoA to (S)-2-benzoylsuccinyl-CoA by hydride transfer to the re-face of nicotinamide adenine dinucleotide (NAD)+. Furthermore, BbsC subunits are not engaged in substrate binding and merely serve as scaffold for the BbsD dimer. BbsCD represents a novel clade of related enzymes within the SDR family, which adopt a heterotetrameric architecture and catalyze the β-oxidation of aromatic succinate adducts.

Intramolecular Cyclization of Vinyldiazoacetates as a Versatile Route to Substituted Pyrazoles

Vinyldiazo compounds undergo a thermal electrocyclization to form pyrazoles in yields of up to 95percent. The reactions are operationally simple, use readily available starting materials, require no intervention of a catalyst, and enable the synthesis of mono-, di- A nd tri-substituted pyrazoles. With the ability to produce highly substituted pyrazoles and the flexibility in installing various types of substituents, this method constitutes a new entry to this valuable heterocyclic scaffold and may be of interest to all branches of the chemical industry.

Novel Base-Free Catalytic Wittig Reaction for the Synthesis of Highly Functionalized Alkenes

A highly efficient catalyst system for base-free catalytic Wittig reactions has been developed and optimized. Initially, several potential (pre)catalysts as well as different silanes as reducing agents were screened. A system based on a readily available

Asymmetric dihydroxylation of β,γ-unsaturated carboxylic esters with trisubstituted C=C bonds - Enantioselective syntheses of trisubstituted γ-butyrolactones

β,γ-Unsaturated esters with stereodefined trisubstitued C=C double bonds were prepared by the Arndt-Eistert homologation of α,β-unsaturated carboxyl halides, by two-step methoxycarbonylation of allylbarium reagents, by deconjugation of α,β-unsaturated esters, and by Horner-Wadsworth-Emmons variants of the Stobbe condensation. Sharpless asymmetric dihydroxylation of the β,γ-unsaturated esters, followed by spontaneous cyclization, afforded β-hydroxy-γ-lactones in moderate to good yields and with enantiomeric excesses of up to 97 %. Similarly, tetrahydroxy-γ-lactones were obtained from diunsaturated esters; these lactones were converted into a bislactone and an unsaturated β-hydroxy γ-lactone. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.

A convenient synthesis of substituted 3-alkoxycarbonyl-β,γ-unsaturated esters with predominant Z-selectivity

The synthesis of substitued 3-alkoxycarbonyl-3β,γ-unsaturated esters with predominant Z-selectivity was discussed. The Z- and E-isomer were separated by column chromatography. The chemical shift of vinyl proton was assigned in the range of δ = 7.82-7.91 as E-isomer, while that in the range of δ = 6.73-6.89 as Z-isomer. The IR spectra of liquid products were determined as films on a Digilab FTS-20E spectrometer.

Preparation of (R)-(-)- and (S)-(+)-3-hydroxymethyl-1-tetralone tosylates, key intermediates in the synthesis of new CNS drugs, via resolution of precursors

The preparation of (R)-(-)- and (S)-(+)-3-hydroxymethyl-1-tetralone tosylates, key intermediates in the synthesis of new CNS drugs in the aminobutyrophenone family, has been developed via classical resolutions or lipase-catalyzed kinetic resolution of one of their precursors.

Succinimide derivatives and process for preparing the same

Novel succinimide derivatives of formula I!: STR1 wherein Ring A is tri-lower alkoxyphenyl, R1 and R2 combine each other to form a group of the formula: or one of R1 and R2 is lower alkoxy, and the other is grou