6578-87-6

Upstream product

• 2002-03-1 2-amino-5-phenyl-1,3,4-thiadiazole 
• 123-08-0 4-hydroxy-benzaldehyde 
• 100-52-7 benzaldehyde 
• 1627-73-2 1-benzylidene thiosemicarbazide 
• 65-85-0 benzoic acid 

Downstream Products

• 107548-34-5 UO₂(NO₃)((C₆H₅)C₂N₂S(NCHC₆H₄(OH)))2(H₂O)2⁽¹⁺⁾*NO₃^(1-) = [UO₂(NO₃)(C₁₅H₁₁N₃SO)2(H₂O)2][NO₃] 
• 107548-32-3 In(Cl)2((C₆H₅)C₂N₂S(NCHC₆H₄(OH)))2(H₂O)2⁽¹⁺⁾*Cl^(1-) = [In(Cl)2(C₁₅H₁₁N₃SO)2(H₂O)2]Cl 

Relevant academic research and scientific papers

Synthesis, Characterization and Biological Evaluation of Some Novel Azo-Imine Compounds

The oxidative cyclization of thiosemicarbazone (III) synthesized from reaction between substituted aryl aldehydes (I) with thiosemicarbazide (II) was done using ferric chloride as oxidative agent to get 2-amino-5-phenyl-1,3,4-thiadiazole (IV). 2-Amino-5-phenyl-1,3,4-thiadiazole was introduced in condensation reactions with substituted aldehydes to obtain benzylidene imine derivatives (VI)1-5. Further these were treated with sulphanilic acid to give new 2-{[5-phenyl-1,3,4-thiadiazole-2-imino] substituted benzene}diazenyl benzene sulfonic acid derivatives (VII)1-5. These derivatives were further characterized by FT-IR, 1H NMR and 13C NMR spectral studies and were screened for antibacterial, antifungal and antioxidant activities.

FeCl3-promoted synthesis of 1,3,4-thiadiazoles under combined microwave and ultrasound irradiation in water

An eco-friendly and efficient synthesis of substituted 1,3,4-thiadiazole derivatives has been developed. This aqueous heterogeneous approach proceeds smoothly and quickly under combined microwave and ultrasound irradiation in the presence of FeCl3.

Synthesis and evaluation of some novel 1,3,4-thiadiazoles for antidiabetic activity

A new series of 1,3,4-thiadiazole derivatives are synthesized and the structures of these compounds have been established on the basis of spectral and elemental analysis. All the compounds are evaluated for antidiabetic activity on albino rats. Most of th

Synthesis of Some Azomethine Derivatives of 2-Amino-5-phenyl-1,3,4-thiadiazole

Azomethines derived from 2-amino-5-phenyl-1,3,4-thiadiazole were prepared by fusion of the starling amine with corresponding carhonyl compound. The method ensures yields of target products up to 97%. The composition and structure of the products were conf

Electronic Spectra and Acidity Constants of Hetero-Aromatic Schiff Bases Derived from 2-Amino-5-phenyl-1,3,4-Thiodiazole and Various Aromatic Aldehydes

The different absorption bands observed in the UV and visible electronic spectra of some arylidene 2-amino-1,3,4-thiodiazole are assigned to the possible electronic transitions.This is made in the light of investigating the spectra of the compounds in pur

KINETICS OF ACID-CATALYSED SHIFF BASE FORMATION BETWEEN 2-AMINO-5-PHENYL-1,3,4-THIADIAZOLE AND AROMATIC ALDEHYDES

The kinetics of the acetic acid-catalysed condensation reaction of 2-amino-5-phenyl-1,3,4-thiadiazole (1) with various aromatic aldehydes has been studied in methanol at different temperatures.The reaction was followed kinetically by measuring the absorbance at the maximum absorption wavelength of the Schiff base formed.In the presence of low concentrations of acetic acid, the reaction is kinetically third-order, first-order in each of 1, aldehyde and acetic acid.On the other hand, in the presence of high acetic acid concentrations, (0.15M), the reaction is totally independent of acid concentration.The rate-determining step of the reaction in the presence of acetic acid as catalyst is suggested to be the dehydration of the carbinolamine intermediate 3.The effect of pH of the acid catalyst (i.e. acetic acid and HCl) on the reaction rate is investigated and discussed.The aldehyde structure-reactivity relationship is illustrated.Furthermore, the effect of the nature of the hydroxylic solvent employed as a reaction medium on the rate of the reaction is studied and discussed.

Electronic Spectra and Acidity Constants of Schiff Bases Derived from 2-Amino-5-phenyl-1,3,4-thiadiazole and Various Aromatic Aldehydes

The different absorption bands observed in the UV and visible electronic spectra of some arylidene-2-amino-1,3,4-thiadiazoles in pure and mixed organic solvents of various polarities as well as in buffer solutions have been assigned.The possibility of the