65783-21-3

Usage

Uses

Used in Pharmaceutical Industry:
N-(4-FLUORO-PHENYL)-GUANIDINE is used as an intermediate for the synthesis of various drugs. Its unique chemical structure allows it to be incorporated into the development of new pharmaceutical compounds, contributing to the advancement of medicine.
Used in Agrochemical Industry:
In the agrochemical industry, N-(4-FLUORO-PHENYL)-GUANIDINE is utilized as an intermediate in the production of agrochemicals. Its ability to act as a building block in organic synthesis aids in the creation of novel compounds and materials that can be applied in agriculture for pest control and crop protection.
Used as a Reagent in Organic Synthesis:
N-(4-FLUORO-PHENYL)-GUANIDINE is used as a reagent in the synthesis of novel compounds and materials. Its versatility in organic synthesis enables the development of new chemical entities with potential applications in various fields, including pharmaceuticals, materials science, and agrochemicals.
Used in Medical Research:
N-(4-FLUORO-PHENYL)-GUANIDINE has been studied for its potential applications in the treatment of certain medical conditions, such as neurodegenerative diseases. Its unique properties and chemical structure make it a promising candidate for further research and development in the medical field, potentially leading to new therapeutic approaches for various conditions.

Upstream product

• 420-04-2 CYANAMID 
• 2146-07-8 p-fluoroaniline hydrochloride 
• 371-40-4 4-fluoroaniline 
• 1610517-94-6 C₂₃H₂₀FN₃O₄ 

Downstream Products

• 467469-98-3 [4-(2,4-dimethyl-1H-pyrrol-3-yl)pyrimidin-2-yl](4-fluorophenyl)amine 
• 880453-77-0 6-ethyl-2-(4-fluorophenylamino)pyrimidin-4-ol 
• 1240673-00-0 4-chloro-6-ethyl-N-(4-fluorophenyl)pyrimidin-2-amine 
• 1394804-81-9 4-ethyl-N-(4-fluorophenyl)-6-(piperidin-1-yl)pyrimidin-2-amine 

Relevant academic research and scientific papers

One-Pot Evolution of Ageladine A through a Bio-Inspired Cascade towards Selective Modulators of Neuronal Differentiation

A bio-inspired cascade reaction has been developed for the construction of the marine natural product ageladine A and a de novo array of its N1-substituted derivatives. This cascade features a 2-aminoimidazole formation that is modeled after an arginine post-translational modification and an aza-electrocyclization. It can be effectively carried out in a one-pot procedure from simple anilines or guanidines, leading to structural analogues of ageladine A that had been otherwise synthetically inaccessible. We found that some compounds out of this structurally novel library show a significant activity in modulating the neural differentiation. Namely, these compounds selectively activate or inhibit the differentiation of neural stem cells to neurons, while being negligible in the differentiation to astrocytes. This study represents a successful case in which the native biofunction of a natural product could be altered by structural modifications.

Discovery of 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine inhibitors of Erk2

The discovery and optimization of a series of tetrahydropyridopyrimidine based extracellular signal-regulated kinase (Erks) inhibitors discovered via HTS and structure based drug design is reported. The compounds demonstrate potent and selective inhibition of Erk2 and knockdown of phospho-RSK levels in HepG2 cells and tumor xenografts.

Discovery of 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine inhibitors of Erk2

The discovery and optimization of a series of tetrahydropyridopyrimidine based extracellular signal-regulated kinase (Erks) inhibitors discovered via HTS and structure based drug design is reported. The compounds demonstrate potent and selective inhibition of Erk2 and knockdown of phospho-RSK levels in HepG2 cells and tumor xenografts.

Synthesis and biological activity of 2-anilino-4-(1H-pyrrol-3-yl) pyrimidine CDK inhibitors

A series of 2-anilino-4-(1H-pyrrol-3-yl)pyrimidines were prepared and evaluated for their ability to inhibit cyclin-dependent kinases (CDKs). A number of analogues were found to be potent CDK2 and CDK4 inhibitors and to exhibit anti-proliferative activity

Solid-phase synthesis of N-aryl-N′-carboalkoxy guanidines by the mitsunobu reaction of Fmoc-guanidines

A new method for the solid-phase synthesis of N-aryl-N′-carboalkoxy guanidines is described. Aromatic amines were reacted with Fmoc-isothiocyanate to provide Fmoc-thioureas, which were coupled with Rink amide resin to provide the corresponding resin-bound Fmoc-guanidines. Subsequent Mitsunobu alkylation with a variety of alcohols delivered N-aryl-N′ carboalkoxy guanidines in good to high purity after resin cleavage.