65786-51-8

Basic information

• Product Name: Methanone, [4-(dimethylamino)phenyl](2-methylphenyl)-
• CAS NO: 65786-51-8
• Molecular Formula: C16H17NO
• Molecular Weight: 239.317
• Mol File: 65786-51-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Methanone, [4-(dimethylamino)phenyl](2-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, [4-(dimethylamino)phenyl](2-methylphenyl)-(65786-51-8)
• EPA Substance Registry System: Methanone, [4-(dimethylamino)phenyl](2-methylphenyl)-(65786-51-8)

Safety Data

• Hazardous Substances Data: 65786-51-8(Hazardous Substances Data)

Upstream product

• 24167-52-0 N,N-dimethyl-3-chlorobenzamide 
• 6699-93-0 (2-methylphenyl)lithium 
• 7055-03-0 2-methyl-N-phenylbenzamide 
• 121-69-7 N,N-dimethyl-aniline 

Relevant articles and documents

One-pot, modular approach to functionalized ketones via nucleophilic addition/Buchwald-Hartwig amination strategy

A general one-pot procedure for the 1,2-addition of organolithium reagents to amides followed by the Buchwald-Hartwig amination with in situ released lithium amides is presented. In this work amides are used as masked ketones, revealed by the addition of organolithium reagents which generates a lithium amide, suitable for subsequent Buchwald-Hartwig coupling in the presence of a palladium catalyst. This methodology allows for rapid, efficient and atom economic synthesis of aminoarylketones in good yields.