658-48-0

Usage

Chemical Properties

off-white fine powder

Uses

A tyrosine hydroxylase inhibitor. An antihypertensive in pheochromocytoma.

InChI:InChI=1/C10H13NO3/c1-11-9(10(13)14)6-7-2-4-8(12)5-3-7/h2-5,9,11-12H,6H2,1H3,(H,13,14)/t9-/m1/s1

Upstream product

• 84713-74-6 2-Amino-3-(4-benzyloxy-phenyl)-2-methyl-propionic acid ethyl ester; hydrochloride 
• 13500-25-9 5-(4-hydroxy-benzyl)-5-methyl-imidazolidine-2,4-dione 
• 95157-52-1 2-{[1-(4-Chloro-phenyl)-meth-(Z)-ylidene]-amino}-3-(4-hydroxy-phenyl)-propionic acid ethyl ester 
• 5619-08-9 tyrosine ethyl ester hydrochloride 
• 13500-24-8 5-(4-methoxybenzyl)-5-methylimidazolidine-2,4-dione 
• 672-87-7 L-methyltyrosine 
• 672-86-6 α-methyl-p-tyrosine 
• 123-08-0 4-hydroxy-benzaldehyde 
• 103-87-7 4-((dimethylamino)methyl)phenol 
• 84713-71-3 3-(4-Benzyloxy-phenyl)-2-{[1-(4-chloro-phenyl)-meth-(Z)-ylidene]-amino}-propionic acid ethyl ester 
• 7383-30-4 2-amino-3-(4-methoxyphenyl)-2-methylpropionic acid 
• 16109-65-2 2-Nitro-2-(4-hydroxybenzyl)propionsaeureethylester 

Downstream Products

• 103-86-6 p-hydroxyamphetamine 
• 121703-96-6 N-Chloroacetyl-α-methyltyrosine 
• 16855-37-1 3-chloro-α-methyl-DL-tyrosine 
• 16855-36-0 3-bromo-α-methyl-DL-tyrosine 
• 16855-39-3 3,5-Dichloro-α-methyltyrosine 
• 16855-38-2 3,5-Dibromo-α-methyltyrosine 
• 16855-34-8 2-amino-2-methyl-3-(3-nitro-4-hydroxyphenyl)-propionic acid 
• 7434-77-7 2-amino-3-(4-hydroxy-3,5-diiodo-phenyl)-2-methyl-propionic acid 
• 779-96-4 3-iodo-α-methyl-DL-tyrosine 
• 443692-61-3 2-Amino-2-methyl-3-(4-benzyloxy-phenyl)-propionic acid hydrobromide salt 
• 4502-13-0 methyl 2-((4-hydroxyphenyl)methyl)-2-aminopropionate 
• 13500-39-5 2-acetamido-3-(4-hydroxyphenyl)-2-methylpropanoic acid 
• 672-87-7 L-methyltyrosine 
• 672-86-6 α-methyl-p-tyrosine 

Relevant academic research and scientific papers

CRYSTALLINE FORMS OF METYROSINE

The disclosure provides crystalline compositions comprising D-metyrosine and L-metyrosine, pharmaceutical formulation comprising one or more crystalline composition described herein and a pharmaceutically acceptable excipient, methods for treating cancer in a patient in need thereof, the method comprising administering to the patient one or more composition described herein, and methods for preparing the compositions described herein.

α-METHYL AMINO ACIDS BY CATALYTIC PHASE-TRANSFER ALKYLATIONS

The α-methyl amino acids, α-methyl p-chlorophenylalanine, α-methyl p-tyrosine, α-methyl m-tyrosine and α-methyl DOPA have been prepared in good yields from amino ester hydrochlorides.The key step in the method is the catalytic phase-transfer alkylation of Schiff base derivatives of monoalkyl amino acids.