65823-91-8

Upstream product

• 75-16-1 methylmagnesium bromide 
• 57677-80-2 2-(4-methoxyphenyl)thiazole-4-carboxylic acid 
• 2362-64-3 p-methoxythiobenzamide 
• 5308-51-0 1-bromobutane-2,3-dione 

Downstream Products

• 65823-80-5 (4-chloro-phenyl)-[2'-(4-methoxy-phenyl)-[4,4']bithiazolyl-2-yl]-amine 
• 65823-79-2 [2'-(4-methoxy-phenyl)-[4,4']bithiazolyl-2-yl]-p-tolyl-amine 
• 65823-78-1 [2'-(4-methoxy-phenyl)-[4,4']bithiazolyl-2-yl]-phenyl-amine 

Relevant academic research and scientific papers

1-(2-(4-methoxyphenyl)thiazolyl-4-yl)ethylamine and synthesis method thereof

The invention belongs to the technical field of organic synthesis, and discloses 1-(2-(4-methoxyphenyl)thiazolyl-4-yl)ethylamine and a chemical synthesis method thereof. The method comprises the following steps: by taking 4-methoxybenzoic acid as a raw material, carrying out acylation, substitution, sulfonylation, substitution, hydrolysis, substitution, substitution and reduction reaction to prepare 1-(2-(4-methoxyphenyl)thiazolyl-4-yl)ethylamine. An efficient synthesis method is provided for synthesis of the compound.

Rh(III)-catalyzed cyclization reaction of azoles with alkynes: Efficient synthesis of azole-fused-pyridines

A Rh(III)-catalyzed cyclization of azoles with alkynes has been developed. A variety of azole-fused-pyridines were obtained in good to excellent yields and regioselectivity. Both the C5 and the C4 position of azoles were suitable for the reaction.