65841-10-3

Upstream product

• 67-56-1 methanol 
• 61203-46-1 3-bromo-4,5-dihydroxybenzoic acid 
• 2150-43-8 3,4-dihydroxybenzoic acid methyl ester 
• 99-50-3 3,4-Dihydroxybenzoic acid 

Downstream Products

• 175668-14-1 3,4-Diacetoxy-5-bromo-benzoic acid methyl ester 
• 1415470-15-3 (2S,3R,4R,5S,6R)-2-(7-chloro-6-(4-cyclopropylbenzyl)benzo[d][1,3]dioxol-4-yl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 
• 175668-17-4 3,4-Diacetoxy-5-((2E,6E)-3,7,11-trimethyl-dodeca-2,6,10-trienyl)-benzoic acid methyl ester 
• 175860-18-1 3,4-dihydroxy-5-farnesylbenzoic acid 
• 50772-79-7 methyl 5-bromo-3,4-dimethoxybenzoate 

Relevant academic research and scientific papers

METHOD FOR PREPARING DIPHENYLMETHANE DERIVATIVES

The present invention relates to an improved process for preparing a diphenyl methane derivative which is useful as an inhibitor of a sodium-dependent glucose transporter (SGLT). Since the process of the present invention is performed by convergent synthe

The biosynthesis of ubiquinone: Synthesis and enzymatic modification of biosynthetic precursors

The synthesis of key intermediates in the eukaryotic biosynthetic pathway of ubiquinone (Q) and the biotransformation of these materials with yeast (S.cerevisiae) mitochondria are described. The synthesis of Q aromatic precursors 2, 3, and 4 (n = 3 in all cases) relies on the palladium (0) catalyzed coupling of farnesyl tributylstannane with suitably functionalized aryl halides. Preliminary experiments show that incubation of synthetic substrate 3 with mitochondria from yeast containing the 3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase gene (COQ3) and S-[methyl-3H]adenosyl-L-methionine yields radiolabeled 4.