65854-71-9

Usage

Uses

Used in Pharmaceutical Synthesis:
2-Acetamido-5-chlorobenzophenone-2',3',4',5',6'-d5 is used as an intermediate in the synthesis of isotope-labeled Desmethyl Diazepam (D291597) for pharmaceutical applications. The incorporation of deuterium atoms in 2-acetamido-5-chlorobenzophenone-2',3',4',5',6'-d5 allows for the production of a labeled version of the primary metabolite of Diazepam, which can be utilized in research and development, as well as in the analysis and monitoring of drug metabolism.
Used in Research and Development:
In the field of research and development, 2-Acetamido-5-chlorobenzophenone-2',3',4',5',6'-d5 is used as a deuterated intermediate for the synthesis of labeled compounds. The use of deuterium-labeled compounds can provide valuable insights into the mechanisms of drug action, metabolism, and pharmacokinetics, as well as aiding in the development of new drugs and therapies.
Used in Analytical Chemistry:
2-Acetamido-5-chlorobenzophenone-2',3',4',5',6'-d5 can be employed in analytical chemistry for the identification and quantification of compounds. The presence of deuterium atoms can enhance the sensitivity and selectivity of analytical techniques, such as mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy, allowing for more accurate and precise measurements.
Used in Drug Metabolism Studies:
In drug metabolism studies, 2-Acetamido-5-chlorobenzophenone-2',3',4',5',6'-d5 can be used to investigate the metabolic pathways and enzymes involved in the breakdown of Diazepam and its metabolites. This information can be crucial for understanding the pharmacological effects, safety, and efficacy of the drug, as well as for the development of personalized medicine strategies.

Upstream product

• 7033-50-3 6-chloro-2-methyl-4H-benzo[d][1,3]oxazin-4-one 
• 4165-57-5 bromobenzene-d5 

Downstream Products

• 65891-80-7 7-chloro-1,3-dihydro-5-(phenyl-d5)-2H-1,4-benzodiazepine-2-one 
• 65854-72-0 2-amino-5-chlorobenzophenone-2',3',4',5',6'-d5 
• 83056-50-2 C₁₆H₅⁽²⁾H₈ClN₂O 

Relevant academic research and scientific papers

Intermediate for preparing diazepam-D5 and diazepam-D8 and preparation method of intermediate

The invention discloses an intermediate for preparing diazepam-D5 and diazepam-D8 and a preparation method of the intermediate. The preparation method comprises the steps: reacting 6-chloro-2-methyl-4H-3,1-benzoxazin-4-one as a raw material with a deuterated bromobenzene Grignard reagent, and carrying out hydrolysis, acylation, cyclization, separation and purification to obtain the intermediate, namely 7-chloro-1,3-dihydro-5-(phenyl-d5)-2H-1,4-benzodiazepin-2-one, for preparing diazepam-D5 and diazepam-D8. The process disclosed by the invention has the characteristics of mild reaction condition, simplicity in operation and the like; and the deuterated diazepam intermediate prepared by using the preparation method is high in chemical purity, high in product quality and good in stability, can be used for preparing standard products of diazepam-D5 and can also be used for preparing standard products of diazepam-D8 and other relevant deuterated standard products.

Diazepam-D5 preparation method

The invention discloses a diazepam-D5 preparation method. According to the method, 6-chlorine-2-methyl-4H-3, 1-benzoxazine-4-ketone (a compound as shown in a formula) serves as a raw material, and the 6-chlorine-2-methyl-4H-3, 1-benzoxazine-4-ketone and deuterated bromobenzene reagents are reacted, hydrolyzed, acylated, cyclized, methylated, separated and purified to obtain diazepam-D5. The preparation method has the advantages of mild reaction condition, simple in operation and the like, and a diazepam-D5 standard product prepared by the method is high in chemical purity and good in quality and stability and can be conveniently used for analyzing preparation of standard products. The preparation method can be used for producing deuterated internal standard substances when the diazepam-D5 is analyzed and detected.

Diazepam-D8 and preparation method thereof

The invention discloses diazepam-D8 and a preparation method thereof. The deuterated diazepam D8 is prepared by reacting 6-chloro-2-methyl-4H-3,1-benzoxazine-4-one (a compound shown as a formula I) serving as a raw material with a deuterated bromobenzene Grignard reagent, and performing hydrolysis, acylation, cyclization, methylation, separation and purification. The process disclosed by the invention has the advantages of mild reaction conditions, simple operation and the like. The deuterated diazepam D8 standard prepared by the method has high chemical purity, good product quality and good stability, and can be conveniently used for the preparation of analytical standards. The preparation method disclosed by the invention can be used for producing a deuterated internal standard substance during analysis and direction of diazepam.