83056-50-2

Upstream product

• 65854-72-0 2-amino-5-chlorobenzophenone-2',3',4',5',6'-d5 
• 65854-71-9 2-acetamido-5-chlorobenzophenone-2',3',4',5',6'-d5 
• 7033-50-3 6-chloro-2-methyl-4H-benzo[d][1,3]oxazin-4-one 
• 4165-57-5 bromobenzene-d5 
• 865-50-9 iodomethane-d3 
• 65891-80-7 7-chloro-1,3-dihydro-5-(phenyl-d5)-2H-1,4-benzodiazepine-2-one 

Relevant academic research and scientific papers

Diazepam-D8 and preparation method thereof

The invention discloses diazepam-D8 and a preparation method thereof. The deuterated diazepam D8 is prepared by reacting 6-chloro-2-methyl-4H-3,1-benzoxazine-4-one (a compound shown as a formula I) serving as a raw material with a deuterated bromobenzene Grignard reagent, and performing hydrolysis, acylation, cyclization, methylation, separation and purification. The process disclosed by the invention has the advantages of mild reaction conditions, simple operation and the like. The deuterated diazepam D8 standard prepared by the method has high chemical purity, good product quality and good stability, and can be conveniently used for the preparation of analytical standards. The preparation method disclosed by the invention can be used for producing a deuterated internal standard substance during analysis and direction of diazepam.