658710-32-8Relevant articles and documents
11H-Isoquino[4,3-c]cinnolin-12-ones: Novel anticancer agents with potent topoisomerase I-targeting activity and cytotoxicity
Ruchelman, Alexander L.,Singh, Sudhir K.,Ray, Abhijit,Wu, Xiaohua,Yang, Jin-Ming,Zhou, Nai,Liu, Angela,Liu, Leroy F.,LaVoie, Edmond J.
, p. 795 - 806 (2004)
Recent studies have identified 2,3-dimethoxy-8,9-methylenedioxy-11-[(2- dimethylamino)ethyl]-11H-isoquino[4,3-c]cinnolin-12-one (1a) as a novel topoisomerase I-targeting agent with potent cytotoxic activity. The effect of varied substituents at the 11-pos