65873-73-6

Usage

Uses

Used in Pharmaceutical Industry:
5-Bromo-6-Methoxynicotinaldehyde is used as an intermediate in the synthesis of various pharmaceutical compounds. Its unique chemical structure allows it to be a key component in the development of new drugs and medications.
Used in Agricultural Chemical Production:
In the agricultural sector, 5-Bromo-6-Methoxynicotinaldehyde is utilized in the production of various agricultural chemicals. Its properties make it suitable for the development of effective and efficient products for crop protection and enhancement.
Used in Organic Synthesis:
5-Bromo-6-Methoxynicotinaldehyde is used as a versatile building block in organic synthesis. Its reactivity and functional groups enable the formation of a wide range of organic compounds, contributing to the advancement of chemical research and development.
Used in Preparation of Pyrazolinone Derivatives:
5-Bromo-6-Methoxynicotinaldehyde is employed in the preparation of pyrazolinone derivatives, which have potential activities in the treatment of various diseases and medical conditions. Its involvement in the synthesis of these derivatives highlights its importance in the development of novel therapeutic agents.

Upstream product

• 13472-60-1 3,5-dibromo-2-methoxypyridine 
• 68-12-2 N,N-dimethyl-formamide 
• 102830-75-1 3-Bromo-5-chloro-2-methoxypyridine 
• 65873-72-5 6-methoxy-3-pyridinecarboxaldehyde 
• 64-17-5 ethanol 
• 1219936-54-5 3-bromo-5-dibromomethyl-2-methoxy-pyridine 

Downstream Products

• 1202277-98-2 (E)-3-bromo-2-methoxy-5-(2-methoxyvinyl)pyridine 
• 1202276-22-9 5-(8-(2-fluorophenyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-N-isopropylthiazol-2-amine 

Relevant academic research and scientific papers

6 - Oxo -1, 6 - dihydropyridine derivative. Preparation method and application thereof in medicine

The invention relates to 6 - oxo -1, 6 - dihydropyridine derivatives, a preparation method and an application thereof in medicine. , The present disclosure relates to I oxo 6 -1 dihydropyridine derivatives represented by the general formula (6 -), a prepa

Novel N-linked aminopiperidine-based gyrase inhibitors with improved hERG and in vivo efficacy against mycobacterium tuberculosis

DNA gyrase is a clinically validated target for developing drugs against Mycobacterium tuberculosis (Mtb). Despite the promise of fluoroquinolones (FQs) as anti-tuberculosis drugs, the prevalence of pre-existing resistance to FQs is likely to restrict their clinical value. We describe a novel class of N-linked aminopiperidinyl alkyl quinolones and naphthyridones that kills Mtb by inhibiting the DNA gyrase activity. The mechanism of inhibition of DNA gyrase was distinct from the fluoroquinolones, as shown by their ability to inhibit the growth of fluoroquinolone-resistant Mtb. Biochemical studies demonstrated this class to exert its action via single-strand cleavage rather than double-strand cleavage, as seen with fluoroquinolones. The compounds are highly bactericidal against extracellular as well as intracellular Mtb. Lead optimization resulted in the identification of potent compounds with improved oral bioavailability and reduced cardiac ion channel liability. Compounds from this series are efficacious in various murine models of tuberculosis.

HETEROARYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS

Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions that include the compounds described herein, and methods of using such antagonists of PGD2 receptors, alone or in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.

TRIAZOLOPYRIDINE COMPOUNDS USEFUL AS KINASE INHIBITORS

A compound of Formula (I) and enantiomers, diastereomers and pharmaceutically-acceptable salts thereof. Also disclosed are pharmaceutical compositions containing compounds of Formula (I), and methods of treating conditions associated with the activity of

IMIDAZOPYRIDINE AND IMIDAZOPYRAZINE COMPOUNDS USEFUL AS KINASE INHIBITORS

A compound of Formula (I) or Formula (II) and enantiomers, diastereomers and pharmaceutically-acceptable salts thereof. Also disclosed are pharmaceutical compositions containing compounds of Formula (I) or Formula (II), and methods of treating conditions

ANTHRANILIC ACID AMIDE DERIVATIVES AND THEIR PHARMACEUTICAL USE

The present invention relates to new anthranilic acid amide derivatives, processes for the preparation thereof, the application thereof in a process for the treatment of the human or animal body, the use thereof - alone or in combination with one or more

Heterocyclic derivatives for the treatment of diabetes and other diseases

The present invention relates to certain substituted heterocycles of Formula (I) which are useful in the treatment of diseases related to lipid and carbohydrate metabolism, such as type 2 diabetes, adipocyte differentiation, uncontrolled proliferation, such as lymphoma, Hodgkin's Disease, leukemia, breast cancer, prostate cancer or cancers in general; and inflammation, such as osteoarthritis, rheumatoid arthritis, Crohn's Disease or Inflammatory Bowel Disease.

N-substituted heterocycles for the treatment of hypercholesteremia, dyslipidemia and other metabolic disorders; cancer, and other diseases

The present invention relates to certain compounds of Formula (I) which can be useful in the treatment of diseases, such as, cancer, metabolic disorders, Type 2 Diabetes, dyslipidemia and/or hyperchloesterolemia:

Oxime derivatives for the treatment of dyslipidemia and hypercholesteremia

The present invention relates to compounds of Formula (I) which may be useful in the treatment of diseases, such as, metabolic disorders, dyslipidemia and/or hyperchloesterolemia: 1

3,4-Dihydro-2-phenyl-2H-pyranopyridines. Novel Aza Analogs of Flavans

Complementary approaches to the synthesis of the title compounds 1 are described.Metallation of 3,5-dibromo-2-methoxypyridine (5b) by bromine/lithium exchange gave selectively the 3-lithio intermediate 6 which was trapped with substituted cinnamaldehydes