65899-16-3Relevant articles and documents
Substituted 2-Pyrones, 2-Pyridones, and Other Congeners of Elasnin as Potential Agents for the Treatment of Chronic Obstructive Lung Diseases
Groutas, William C.,Stanga, Michael A.,Brubaker, Michael J.,Huang, Tien L.,Moi, Min K.,Carroll, Robert T.
, p. 1106 - 1109 (2007/10/02)
Several congeners of elasnin (I) have been synthesized and shown to inhibit human leukocyte elastase (HLE).The C-3 alkyl substituted 2-pyrones 11 and 12 were found to be most inhibitors of the enzyme.These compounds are highly specific in their inhibitory