65913-22-6Relevant academic research and scientific papers
Synthesis of extended oxazoles II: Reaction manifold of 2-(halomethyl)-4,5-diaryloxazoles
Patil, Pravin C.,Luzzio, Frederick A.
supporting information, p. 757 - 759 (2016/02/05)
2-(Halomethyl)-4,5-diphenyloxazoles are effective, reactive scaffolds which can be utilized for synthetic elaboration at the 2-position. Through substitution reactions, the chloromethyl analogue is used to prepare a number of 2-alkylamino-, 2-alkylthio-, and 2-alkoxy-(methyl) oxazoles. The 2-bromomethyl analogue offers a more reactive alternative to the chloromethyl compounds and is useful in the C-alkylation of a stabilized (malonate) carbanion as exemplified by a concise synthesis of Oxaprozin.
Nonprostanoid prostacyclin mimetics. 4. Derivatives of 2-[3-[2-(4,5- diphenyl-2-oxazolyl)ethyl]phenoxy]acetic acid substituted α to the oxazole ring
Meanwell,Rosenfeld,Wright,Brassard,Buchanan,Federici,Fleming,Gamberdella,Hartl,Zavoico,Seiler
, p. 3871 - 3883 (2007/10/02)
The 4,5-diphenyloxazole derivatives 2-4 were previously identified as nonprostanoid prostacyclin (PGI2) mimetics. A series of derivatives of 2-4 bearing substitutents at the carbon atom α to the oxazole ring were synthesized and evaluated as in
