65939-65-3

Basic information

• Product Name: diethyl 3,5-diphenyl-2H-pyrrole-2,2-dicarboxylate
• CAS NO: 65939-65-3
• Molecular Formula: C₂₂H₂₁NO₄
• Molecular Weight: 363.4064
• Mol File: 65939-65-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 455°C at 760 mmHg
• Flash Point: 165.6°C
• Density: 1.14g/cm³
• Vapor Pressure: 1.83E-08mmHg at 25°C
• Refractive Index: 1.569
• CAS DataBase Reference: diethyl 3,5-diphenyl-2H-pyrrole-2,2-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl 3,5-diphenyl-2H-pyrrole-2,2-dicarboxylate(65939-65-3)
• EPA Substance Registry System: diethyl 3,5-diphenyl-2H-pyrrole-2,2-dicarboxylate(65939-65-3)

Safety Data

• Hazardous Substances Data: 65939-65-3(Hazardous Substances Data)

Upstream product

• 65939-64-2 (±)-diethyl 3,5-diphenyl-3,4-dihydro-2H-pyrrole-2,2-dicarboxylate 
• 6829-40-9 aminomalonic acid diethyl ester 
• 13433-00-6 diethyl aminomalonate hydrochloride 
• 120-46-7 1,3-diphenylpropanedione 
• 94-41-7 benzalacetophenone 
• 100784-99-4 2-((Z)-3-Oxo-1,3-diphenyl-propenylamino)-malonic acid diethyl ester 

Downstream Products

• 91307-93-6 3,5-diphenyl pyrrole-1,2-dicarboxylate de diethyle 
• 53778-26-0 3,5-diphenyl-1H-pyrrole-2-carboxylic acid ethyl ester 

Relevant articles and documents

Aryl and ethoxycarbonyl derivatives of pyrroles, 2H pyrroles and 3,4-dihydropyrroles and their immunoactivity of human T lymphocytes

Several pyrroles, 2H pyrroles, 3,3-dihydropyrroles substituted in various positions with phenyl and ethoxycarbonyl groups, were prepared in order to study in vitro their immunoactivity on human T lymphocytes. The best action was observed when on the pyrrole cycle, a carboxylic chain in position 2, an aromatic cycle in 5, and a substituent in 3, particularly a phenyl or a carboxylic ester were simultaneously found to exist. A conformational approach, performed by magnetic anisotropy quantification of phenyls, using Johnson and Bovey increments, showed that the orthogonality of the substituent in 3 is important as regards the pyrrolic cycle. Thus, the ethyl 3,5-diphenylpyrrole-2-carboxylate ester 8 appears to be the most interesting as it is more efficient than the levamisole chlorhydrate in the tests connected with the lymphoblastic transformation in presence of PHA (phyto-hemagglutinin) and related to the mobilisation of CD2 receptors.