53778-26-0

Upstream product

• 142835-03-8 ethyl (Z)-2-(3-oxo-1,3-diphenylprop-1-enylamino)acetate 
• 65939-64-2 (±)-diethyl 3,5-diphenyl-3,4-dihydro-2H-pyrrole-2,2-dicarboxylate 
• 98-86-2 acetophenone 
• 13302-76-6 monothiodibenzoylmethane 
• 623-33-6 glycine ethyl ester hydrochloride 
• 7338-94-5 1,3-diphenyl-2-propynone 
• 100-52-7 benzaldehyde 
• 536-74-3 phenylacetylene 
• 614-47-1 1,3-diphenyl-propen-3-one 
• 57957-24-1 N-(1-phenylvinyl)acetamide 
• 2216-94-6 phenylpropynoic acid ethyl ester 
• 613-91-2 acetophenone oxime 
• 23464-17-7 1,3-diphenylpropane-1,2-dione 
• 13433-00-6 diethyl aminomalonate hydrochloride 

Downstream Products

• 858271-82-6 (3,5-diphenyl-pyrrol-2-yl)-methanol 
• 16206-35-2 3,5-diphenyl-2-methyl-1H-pyrrole 

Relevant academic research and scientific papers

Regioselective competitive synthesis of 3,5-bis(het) aryl pyrrole-2-carboxylates/carbonitriles vs. β-enaminones from β-thioxoketones

An easily adaptable protocol for the synthesis of 3,5-bis(het)aryl-2-carboxylate/nitrile pyrroles and the related 2,3,5-tri(het)aryl-pyrroles with complementary regioselectivity from the corresponding 1,3-bis(het)aryl-1,3-monothio diketones or β-enaminone precursors has been reported. Initially, regioselective base catalyzed condensation of glycine ethyl/methyl esters or aminoacetonitrile with 1,3-bis(het)aryl-1,3-monothio diketones give β-enaminones, which then in-situ undergoes cyclization to form 3,5-bis(het)aryl-2-carboxylate/nitrile pyrroles. The synthesis of 2,3,5 tri substituted pyrroles with full control over 3rd & 5th position on pyrrole ring is the noteworthy feature of this protocol. Although the product yields are moderate to good, the method offers a facile regioselective entry to 2,3,5 trisubstituted pyrroles without the aid of transition metal.

DBU-promoted tandem Michael-addition/cyclization for the synthesis of polysubstituted pyrroles

An efficient and transition-metal-free method for the synthesis of the structurally diversified pyrroles is described. Various α,β-unsaturated ynones reacted with N-substituted ethyl glycine ethyl ester hydrochlorides in the presence of DBU to form the co

2,3,5 TRISUBSTITUTED PYRROLE DERIVATIVES AS TOPOISOMERASE INHIBITORS AND THERAPEUTIC USES THEREOF

The compounds of Formula (1) having topoisomerase inhibitory effect includes [Formula should be inserted here] wherein, R1 is selected from a group consisting of H, OR5, optionally substituted C1-C12 alkyl, haloalkyl, C2-C12alkenyl, C2-C12alkynyl, C1-C12alkyloxy, C1-C12haloalkyloxy, C2-C10 heteroalkyl, C3- C12 cycloalkyl, C3-C12cycloalkenyl, C2- C12heterocycloalkyl, C2-C2 heterocycloalkenyl, C6-C18aryl, and C1-C18heteroaryl; R2, R3 and R4 are independently selected from a group consisting of H, halogen, CN, - NO2, SH, CF3, OH, CO2H, CONH2, OCF3, optionally substituted C1-C12alkyl, optionally substituted C1-C12haloalkyl optionally substituted C2-C12alkenyl, optionally substituted C2- C12alkynyl, optionally substituted C1-C12alkyloxy, optionally substituted C1- C12haloalkyloxy, optionally substituted C2-C12heteroalkyl, optionally substituted C3- C12cycloalkyl, optionally substituted C3-C12 cycloalkenyl, optionally substituted C2-C12 heterocycloalkyl, optionally substituted C2-C12 heterocycloalkenyl, optionally substituted C6- C18aryl, and optionally substituted C1-C18heteroaryl; R5 is selected H, optionally substituted C1-C12alkyl, optionally substituted C2- C12alkenyl, optionally substituted optionally substituted C1-C12 haloalkyl, optionally substituted C3-C12cycloalkyl, optionally substituted C6- C18aryl, and optionally substituted C1- Ci18heteroaryl; or a pharmaceutically acceptable salt, N-oxide, or prodrug thereof.

Transition Metal-Free Synthesis of 3-Alkynylpyrrole-2-carboxylates via Michael Addition/Intramolecular Cyclodehydration

A transition metal-free and efficient method for the synthesis of 3-alkynylpyrrole-2-carboxylates from diynones and glycine esters or 2-aminoacetophenone hydrochloride has been developed. This transformation provides a large range of substituted pyrroles in good to excellent yields with the elimination of water as the only by-product. The detailed mechanistic studies elucidated that this transformation involves a Michael addition/intramolecular cyclodehydration process. (Figure presented.) .

Copper-promoted oxidative coupling of enamides and alkynes for the synthesis of substituted pyrroles

An efficient copper-promoted oxidative coupling of enamides with alkynes has been developed for the synthesis of substituted pyrroles. The reaction proceeded through C-H and N-H bond functionalization of enamides under mild conditions.

One-pot synthesis of pyrrole-2-carboxylates and -carboxamides via an electrocyclization/oxidation sequence

An electrocyclic ring closure is the key step of an efficient one-pot method for the synthesis of pyrrole-2-carboxylates and -carboxamides from chalcones and glycine esters or amides. The 3,4-dihydro-2H-pyrrole intermediates generated in situ are oxidized

Synthesis of multi-substituted pyrroles using enamides and alkynes catalyzed by Pd(OAc)2 with molecular oxygen as an oxidant

A cyclization reaction between enamides and alkynes catalyzed by palladium(ii) acetate is described. In this method, the molecular oxygen serves as an efficient oxidant for the Pd(ii)/Pd(0) catalytic cycle. The simple reaction conditions permit this methodology to be used as a general tool for the preparation of multi-substituted pyrroles.

A solvent-free synthesis of ethyl 3,5-diaryl-1H-pyrrole-2-carboxylates via triethylphosphite mediated reductive cyclization of ethyl 2-nitro-5-oxo-3,5- diarylpentanoates under microwave irradiation

Ethyl 3,5-diaryl-1H-pyrrole-2-carboxylates have been synthesized in good yields from ethyl 2-nitro-5-oxo-3,5-diarylpentanoates by treatment with triethylphosphite under microwave irradiation. The integrity of the mechanism proposed has been augmented by

ORGANIC METAL COMPLEXES FOR USE IN OPTOELECTRONIC DEVICES

The invention provides an organic metal complex represented by the formula (I), wherein M is a metal selected from Rh, Ir, or Pt; Y represents N or O; R1 represents a hydrogen, a halogen, a nitro group, an amino group, a hydroxyl group, a C3-C40 aromatic radical, a C1-C50 aliphatic radical, and a C3-C50 cycloaliphatic radical; R2 represents a hydrogen, C3-C20 aromatic radical, C1-C50 aliphatic radical, or a C3-C50 cycloaliphatic radical; or R1 and R2, together with the adjacent Y, may form a ring, preferably a 5- or 6-membered ring; n1 has a value of from 0 to 3; and n2 has a value of 0 to 2; m1 has a value of at least 1; and m2 has a value of at least 1 provided that m1+m2 is 3.

A study of the effects of subunit pre-orientation for diarylpyrrole esters; design of new aryl-heteroaryl fluorescent sensors

The synthesis, single crystal X-ray structures, spectroscopic properties and molecular mechanics calculations of three systematically substituted 3,5-diaryl-1H-pyrrole-2-carboxylic acid ethyl esters 1a-c are described. The goal is to develop design princi