65945-22-4Relevant academic research and scientific papers
Design, Synthesis, and Structure-Activity Relationship Study of Pyrazolones as Potent Inhibitors of Pancreatic Lipase
Zhang, Jing,Yang, Yang,Qian, Xing-Kai,Song, Pei-Fang,Zhao, Yi-Shu,Guan, Xiao-Qing,Zou, Li-Wei,Bao, Xiaoze,Wang, Hong
, p. 1600 - 1604 (2021/03/03)
Pancreatic lipase (PL), a key target for the prevention and treatment of obesity, plays crucial roles in the hydrolysis and absorption of in dietary fat. In this study, a series of pyrazolones was synthesized, and their inhibitory effects against PL were
Discovery of pyrazolones as novel carboxylesterase 2 inhibitors that potently inhibit the adipogenesis in cells
Qian, Xing-Kai,Zhang, Jing,Song, Pei-Fang,Zhao, Yi-Su,Ma, Hong-Ying,Jin, Qiang,Wang, Dan-Dan,Guan, Xiao-Qing,Li, Shi-Yang,Bao, XiaoZe,Zou, Li-Wei
, (2021/05/10)
Carboxylesterase 2 (CES2) is one of the most important Phase I drug metabolizing enzymes in the carboxylesterase family. It plays crucial roles in the bioavailability of oral ester prodrugs and the therapeutic effect of some anticancer drugs such as irino
