65964-65-0Relevant academic research and scientific papers
Metal-free C-H arylation of imidazoheterocycles with aryl hydrazines
Jana, Sourav,Samanta, Sadhanendu,Bagdi, Avik K.,Shirinian, Valerii Z.,Hajra, Alakananda
, p. 12360 - 12367 (2018/04/12)
A simple and efficient metal-free arylation of imidazo[1,2-a]pyridines at the C-3 position with arylhydrazine has been achieved at room temperature under ambient air conditions. Various 2,3-disubstituted imidazopyridines and imidazothiazoles were synthesized with high yields. The present methodology demonstrates the usefulness of commercially available aryl hydrazine as an arylating agent.
Method for synthesizing benzimidazole compound and agricultural biological activity thereof
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Paragraph 0060-0062; 0066, (2018/12/05)
The invention provides a method for synthesizing a benzimidazole compound and the agricultural biological activity thereof, and belongs to the field of organic synthesis. The method has the advantagesof low raw material cost, no need of heating a reaction
Transition-metal-free C-C bond cleavage and formation: Efficient synthesis of 2,3-diarylimidazo[1,2-α]pyridines from 2-aminopyridines and alkynoates
Chen, Zhengwang,Wen, Yuelu,Luo, Guotian,Ye, Min,Wang, Qinghao
, p. 86464 - 86467 (2016/11/05)
A highly efficient transition-metal-free cyclization reaction for the synthesis of 2,3-diarylimidazo[1,2-α]pyridines is described. A variety of substituted 2-aminopyridines and alkynoates are compatible under the standard conditions. This protocol is marked by the cleavage of a C-C bond and the formation of a new Csp2-Csp2 bond under transition-metal-free conditions.
Straightforward synthesis of various 2,3-diarylimidazo[1,2-a]pyridines in peg400 medium through one-pot condensation and C-H arylation
Hiebel, Marie-Aude,Fall, Yacoub,Scherrmann, Marie-Christine,Berteina-Raboin, Sabine
, p. 4643 - 4650 (2014/08/05)
PEG400 is described herein as a suitable medium for the condensation of various 2-amino pyridines with α-bromo ketones. 2-Arylimidazo[1,2-a]pyridines were synthetized in a short time through microwave irradiation in moderate to excellent yields
Copper-catalyzed synthesis of imidazo[1,2-a]pyridines through tandem imine formation-oxidative cyclization under ambient air: One-step synthesis of zolimidine on a gram-scale
Bagdi, Avik Kumar,Rahman, Matiur,Santra, Sougata,Majee, Adinath,Hajra, Alakananda
supporting information, p. 1741 - 1747 (2013/07/11)
A new copper-catalyzed oxidative cyclization via C-H amination between 2-aminopyridines and methyl aryl/heteroaryl ketones has been developed under ambient air. Imidazo[1,2-a]pyridines containing a wide range of functional groups have been synthesized from basic and easily available starting materials. This simple, one-pot reaction protocol is applicable for the direct preparation of zolimidine (a marketed antiulcer drug) on a large scale. Copyright
