65964-65-0Relevant academic research and scientific papers
Method for synthesizing benzimidazole compound and agricultural biological activity thereof
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Paragraph 0060-0062; 0066, (2018/12/05)
The invention provides a method for synthesizing a benzimidazole compound and the agricultural biological activity thereof, and belongs to the field of organic synthesis. The method has the advantagesof low raw material cost, no need of heating a reaction
Metal-free C-H arylation of imidazoheterocycles with aryl hydrazines
Jana, Sourav,Samanta, Sadhanendu,Bagdi, Avik K.,Shirinian, Valerii Z.,Hajra, Alakananda
, p. 12360 - 12367 (2018/04/12)
A simple and efficient metal-free arylation of imidazo[1,2-a]pyridines at the C-3 position with arylhydrazine has been achieved at room temperature under ambient air conditions. Various 2,3-disubstituted imidazopyridines and imidazothiazoles were synthesized with high yields. The present methodology demonstrates the usefulness of commercially available aryl hydrazine as an arylating agent.
Transition-metal-free C-C bond cleavage and formation: Efficient synthesis of 2,3-diarylimidazo[1,2-α]pyridines from 2-aminopyridines and alkynoates
Chen, Zhengwang,Wen, Yuelu,Luo, Guotian,Ye, Min,Wang, Qinghao
, p. 86464 - 86467 (2016/11/05)
A highly efficient transition-metal-free cyclization reaction for the synthesis of 2,3-diarylimidazo[1,2-α]pyridines is described. A variety of substituted 2-aminopyridines and alkynoates are compatible under the standard conditions. This protocol is marked by the cleavage of a C-C bond and the formation of a new Csp2-Csp2 bond under transition-metal-free conditions.
Straightforward synthesis of various 2,3-diarylimidazo[1,2-a]pyridines in peg400 medium through one-pot condensation and C-H arylation
Hiebel, Marie-Aude,Fall, Yacoub,Scherrmann, Marie-Christine,Berteina-Raboin, Sabine
, p. 4643 - 4650 (2014/08/05)
PEG400 is described herein as a suitable medium for the condensation of various 2-amino pyridines with α-bromo ketones. 2-Arylimidazo[1,2-a]pyridines were synthetized in a short time through microwave irradiation in moderate to excellent yields
Copper-catalyzed synthesis of imidazo[1,2-a]pyridines through tandem imine formation-oxidative cyclization under ambient air: One-step synthesis of zolimidine on a gram-scale
Bagdi, Avik Kumar,Rahman, Matiur,Santra, Sougata,Majee, Adinath,Hajra, Alakananda
supporting information, p. 1741 - 1747 (2013/07/11)
A new copper-catalyzed oxidative cyclization via C-H amination between 2-aminopyridines and methyl aryl/heteroaryl ketones has been developed under ambient air. Imidazo[1,2-a]pyridines containing a wide range of functional groups have been synthesized from basic and easily available starting materials. This simple, one-pot reaction protocol is applicable for the direct preparation of zolimidine (a marketed antiulcer drug) on a large scale. Copyright
