65985-76-4

Upstream product

• 62750-39-4 ((S)-1-Benzyl-2-imidazol-1-yl-2-oxo-ethyl)-carbamic acid benzyl ester 
• 38330-80-2 monomethyl monopotassium malonate 
• 1161-13-3 N-Cbz-L-Phe 
• 79-20-9 acetic acid methyl ester 

Downstream Products

• 118219-42-4 methyl (3S,4S)-4-(((benzyloxy)carbonyl)amino)-3-hydroxy-5-phenylpentanoate 

Relevant academic research and scientific papers

α-Amino acid derived enaminones and their application in the synthesis of N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates and other heterocycles

A new and simple synthesis of novel N-protected methyl 5-substituted-4- hydroxypyrrole-3-carboxylates, which exist in equilibrium with their 4-oxo tautomers, has been developed in two steps starting from N-protected α-amino acids. The key intermediates ar

Synthesis and transformations of novel L -phenylalanine derived pyrazolidin-3-ones

A simple and straightforward four-step synthesis of novel diastereomeric L-phenylalanine-derived pyrazolidin-3-ones is described. The absolute configuration of the novel C(5) stereogenic centre has been unambiguously determined by single crystal X-ray analysis and via chemical interconversions. A series of novel thiourea derived pyrazolidinones have been prepared and tested as potential organocatalysts. N(1) un-substituted pyrazolidinones can be used for the construction of a novel type of bicyclic heterocycles and other selective derivatizations. 2013 Wiley Periodicals, Inc.

Decarboxylative Carbon Acylation of Malonates with Aminoacylimidazoles Mediated by Lewis Acids

Various N-protected aminoacylimidazoles undergo decarboxylative carbon acylation with sodium or potassium monomethylmalonate in THF in the presence of MgCl2, CoCl2 or MnCl2 to give dipeptide analogues (3) in 45-82percent isolated yield.Amino ketoester (3e) undergoes intramolecular cyclization induced by diisopropylethylamine and anhydrous magnesium chloride to trisubstituted tetramic acid (4).