65996-43-2

Upstream product

• 3982-18-1 1,2-diphenyl-2-p-toluenesulfonyliminoethanone 
• 32493-66-6 2-(2-oxo-1,2-diphenylethyl)isoindoline-1,3-dione 
• 1484-50-0 desyl bromide 
• 885-75-6 2-amino-1,2-diphenyl-ethanone; hydrochloride 
• 98-59-9 p-toluenesulfonyl chloride 
• 451-40-1 phenyl benzyl ketone 
• 97305-99-2 N-(2,2-diphenylvinyl)-4-methylbenzenesulfonamide 
• 5344-88-7 benzil monohydrazone 
• 645-49-8 cis-stilben 
• 127-65-1 chloroamine-T 

Downstream Products

• 959429-17-5 C₂₇H₂₉NO₃S 
• 910895-90-8 C₂₉H₂₅NO₃S 
• 3316-42-5 N-(2-hydroxy-1,2-diphenylethyl)-4-methylbenzenesulfonamide 
• 176706-54-0 N-((1S,2R)-2-hydroxy-1,2-diphenylethyl)-4-methylbenzene sulfonamide 
• 176298-49-0 (1S,2R)-(+)-2-amino(SO₂-p-C₆H₄CH₃)-1,2-diphenylethanol 
• 3316-42-5 rel-N-((1R,2S)-2-hydroxy-1,2-diphenylethyl)-4-methylbenzenesulfonamide 
• 1448349-70-9 1-allyl-2,3,5-triphenyl-4-tosyl-1H-pyrrole 
• 1019853-29-2 1(S),2(R),5(R)-diphenyltetrahydro-1aH-oxireno[2,3-c]pyrrol-3-yl (4-methylphenyl) sulfone 

Relevant academic research and scientific papers

Asymmetric Transfer Hydrogenation: Dynamic Kinetic Resolution of α-Amino Ketones

A series of α-amino ketones were reduced using asymmetric transfer hydrogenation (ATH) through a dynamic kinetic resolution (DKR). The protecting group was matched to the reducing agent, and following optimization, a series of substrates were investigated, giving products in high diastereoselectivity, over 99% ee in several cases and full conversion. The methodology was applied to the enantioselective synthesis of an MDM2-p53 inhibitor precursor.

An iodine(iii) mediated oxidative rearrangement of enamines: efficient synthesis of α-amino ketones

An iodine(iii)-mediated, group-selective oxidative rearrangement of β,β-diarylenamines to α-amino ketones has been accomplished with excellent yield. The developed reaction involves the initial oxidation of enamine to an α-acyloxyimine intermediate and concomitant semipinacol rearrangement.

A general approach to polysubstituted pyrroles

Exposure of a range of 3-hydroxy-2-sulfonylamino-4-alkynes to excess iodine delivers good yields of a series of iodopyrroles. Unexpectedly, the hydroxyl-dihydropyrroles, which were assumed to be the first-formed intermediates, turn out to be stable entities which have been isolated for the first time.

First osmium-catalysed ketamination of alkenes

Conditions for a first oxidative conversion of alkenes into 2-amino ketones are described, which yield racemic products within a direct oxidation pathway and 2-amino ketones with up to 99% enantiomeric excess from the corresponding enantiopure amino alcohols. The Royal Society of Chemistry 2005.

Chemoselective reduction of α-imino carbonyl compounds into α-amino carbonyl compounds with titanium tetraiodide

α-Imino carbonyl compounds are chemoselectively reduced with titanium tetraiodide to give α-amino carbonyl compounds in good to excellent yields.

New insertion reactions of some carbenoids into amide- and sulfonamide-NH bonds

In the presence of catalytic amounts of Rh2(OAc)4 in toluene, dimethyl diazomalonate (1) decomposed with evolution of N2 to form a carbenoid of type 8 which reacted with carboxamides 2 and toluenesulfonamide (4) to give 2-(acylamino)- and 2-(sulfonylamino)malonates 3 and 5, respectively. In an analogous reaction, α-diazo ketone 6 and 4 yielded N-(2-oxo-1,2-diphenylethyl)toluenesulfonamide (7).