66003-50-7

Basic information

• Product Name: 1-(6-hydroxy-1,3-benzodioxol-5-yl)Ethanone
• Synonyms: 1-(6-hydroxy-1,3-benzodioxol-5-yl)Ethanone;1-(6-hydroxy-2H-1,3-benzodioxol-5-yl)ethan-1-one;1-(6-Hydroxy-benzo[1,3]dioxol-5-yl)-ethanone
• CAS NO: 66003-50-7
• Molecular Formula: C₉H₈O₄
• Molecular Weight: 180.15742
• Mol File: 66003-50-7.mol
• Article Data: 12

Chemical Properties

• Melting Point: 114 °C
• Boiling Point: 344.3±42.0 °C(Predicted)
• Appearance: /
• Density: 1.379±0.06 g/cm3(Predicted)
• PKA: 10.29±0.20(Predicted)
• CAS DataBase Reference: 1-(6-hydroxy-1,3-benzodioxol-5-yl)Ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(6-hydroxy-1,3-benzodioxol-5-yl)Ethanone(66003-50-7)
• EPA Substance Registry System: 1-(6-hydroxy-1,3-benzodioxol-5-yl)Ethanone(66003-50-7)

Safety Data

• Hazardous Substances Data: 66003-50-7(Hazardous Substances Data)

Usage

Preparation

Obtained by refluxing methylene iodide and 2,4,5-trihydroxyacetophenone in acetone in the presence of potassium carbonate (56%) (51%).

Upstream product

• 533-31-3 Sesamol 
• 75-36-5 acetyl chloride 
• 75-11-6 diiodomethane 
• 1818-27-5 1-(2,4,5-trihydroxyphenyl)ethanone 
• 75-05-8 acetonitrile 
• 108-24-7 acetic anhydride 
• 326-58-9 acetic acid benzo[1,3]dioxol-5-yl ester 

Downstream Products

• 1262429-53-7 (E)-3-(3-fluoro-4-methoxyphenyl)-1-(5-methoxybenzo[d][1,3]dioxol-6-yl)prop-2-en-1-one 
• 1262429-52-6 (E)-3-(4-methoxyphenyl)-1-(5-methoxybenzo[d][1,3]dioxol-6-yl)prop-2-en-1-one 
• 1262428-76-1 (E)-3-(2-chlorophenyl)-1-(5-methoxybenzo[d][1,3]dioxol-6-yl)prop-2-en-1-one 
• 1262428-75-0 (E)-3-(4-bromophenyl)-1-(5-methoxybenzo[d][1,3]dioxol-6-yl)prop-2-en-1-one 

Relevant articles and documents

TRICYCLIC COMPOUNDS ACTING ON CRBN PROTEINS

The present invention discloses a series of tricyclic compounds and use thereof in preparing a medicament for treating a disease related to CRBN protein. Specifically, the present invention discloses a derivative compound of formula (1) or a pharmaceutically acceptable salt thereof.

A functional and self-assembling octyl-phosphonium-tagged esculetin as an effective siRNA delivery agent

Herein, we document a self-assembling octyl-TPP tagged esculetin (Mito-Esc) as functionally active and as a novel small molecule siRNA delivery vector. While Mito-Esc itself induces selective breast cancer cell death, the amphiphilic nature of Mito-Esc delivers therapeutic siRNAs intracellularly without the need for any excipient to exacerbate the anti-proliferative effects.

In the mists of a fungal metabolite: An unexpected reaction of 2,4,5-trimethoxyphenylglyoxylic acid

The reactions of phenylglyoxylic acids during the synthesis and biological evaluation of fungal metabolites led to the discovery of hitherto unknown compounds with a p-quinone methide (p-QM) structure. The formation of these p-QMs using 13C-lab