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66003-50-7

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66003-50-7 Usage

Preparation

Obtained by refluxing methylene iodide and 2,4,5-trihydroxyacetophenone in acetone in the presence of potassium carbonate (56%) (51%).

Check Digit Verification of cas no

The CAS Registry Mumber 66003-50-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,0,0 and 3 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 66003-50:
(7*6)+(6*6)+(5*0)+(4*0)+(3*3)+(2*5)+(1*0)=97
97 % 10 = 7
So 66003-50-7 is a valid CAS Registry Number.

66003-50-7Relevant articles and documents

TRICYCLIC COMPOUNDS ACTING ON CRBN PROTEINS

-

, (2021/07/17)

The present invention discloses a series of tricyclic compounds and use thereof in preparing a medicament for treating a disease related to CRBN protein. Specifically, the present invention discloses a derivative compound of formula (1) or a pharmaceutically acceptable salt thereof.

Effect of the Chromone Core Substitution of Dirchromone on the Resultant Biological Activities

St-Gelais, Alexis,Alsarraf, Jér?me,Legault, Jean,Plourde, Joanne,Pichette, André

, p. 2786 - 2794 (2021/12/02)

Dirchromone is a bioactive vinyl sulfoxide-bearing chromone first isolated from the shrub Dirca palustris. Altogether, 32 of its derivatives were prepared to assess the effect of substitution of its chromone core upon activities against cancer cell lines, Gram-positive bacteria, and fungi (such as Candida albicans). All compounds were synthesized following a synthetic strategy involving Pummerer and soft-enolization Baker-Venkataraman rearrangements. Substituent position changes induced little variability on the activities tested. There was no correlation between cytotoxic and antibacterial effects, suggesting different underlying mechanisms of action. In particular, hydroxy group and cyanide substituents diminished cytotoxicity, with the latter featuring enhanced antibacterial activity. Higher homologues of 6-alkoxydirchromones also exhibited progressively emerging antifungal activity. Other modifications had moderate effects on cytotoxicity with some derivatives leading to increased potency. This behavior highlights the robustness of the natural dirchromone pharmacophore toward decoration, thus paving the way for more elaborate future drug design.

In the mists of a fungal metabolite: An unexpected reaction of 2,4,5-trimethoxyphenylglyoxylic acid

Csuk, René,Liebing, Phil,Loesche, Anne,Serbian, Immo,Sommerwerk, Sven,Str?hl, Dieter

, (2020/04/29)

The reactions of phenylglyoxylic acids during the synthesis and biological evaluation of fungal metabolites led to the discovery of hitherto unknown compounds with a p-quinone methide (p-QM) structure. The formation of these p-QMs using 13C-lab

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