66003-50-7Relevant articles and documents
TRICYCLIC COMPOUNDS ACTING ON CRBN PROTEINS
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Paragraph 0101; 0103, (2021/07/17)
The present invention discloses a series of tricyclic compounds and use thereof in preparing a medicament for treating a disease related to CRBN protein. Specifically, the present invention discloses a derivative compound of formula (1) or a pharmaceutically acceptable salt thereof.
A functional and self-assembling octyl-phosphonium-tagged esculetin as an effective siRNA delivery agent
Shaikh, Altab,Neeli, Praveen Kumar,Singuru, Gajalakshmi,Panangipalli, Sravya,Banerjee, Rajkumar,Maddi, Sridhar Reddy,Thennati, Rajamannar,Bathula, Surendar Reddy,Kotamraju, Srigiridhar
supporting information, p. 12329 - 12332 (2021/12/07)
Herein, we document a self-assembling octyl-TPP tagged esculetin (Mito-Esc) as functionally active and as a novel small molecule siRNA delivery vector. While Mito-Esc itself induces selective breast cancer cell death, the amphiphilic nature of Mito-Esc delivers therapeutic siRNAs intracellularly without the need for any excipient to exacerbate the anti-proliferative effects.
In the mists of a fungal metabolite: An unexpected reaction of 2,4,5-trimethoxyphenylglyoxylic acid
Csuk, René,Liebing, Phil,Loesche, Anne,Serbian, Immo,Sommerwerk, Sven,Str?hl, Dieter
, (2020/04/29)
The reactions of phenylglyoxylic acids during the synthesis and biological evaluation of fungal metabolites led to the discovery of hitherto unknown compounds with a p-quinone methide (p-QM) structure. The formation of these p-QMs using 13C-lab