6601-00-9

Basic information

• Product Name: 1,3-bis(3-methoxyphenyl)thiourea
• Synonyms: 1,3-Bis(3-methoxyphenyl)thiourea; N,N'-di(3-methoxyphenyl)thiourea; thiourea, N,N'-bis(3-methoxyphenyl)-
• CAS NO: 6601-00-9
• Molecular Formula: C₁₅H₁₆N₂O₂S
• Molecular Weight: 288.3647
• Mol File: 6601-00-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 415°C at 760 mmHg
• Flash Point: 204.8°C
• Density: 1.277g/cm³
• Vapor Pressure: 4.26E-07mmHg at 25°C
• Refractive Index: 1.683
• CAS DataBase Reference: 1,3-bis(3-methoxyphenyl)thiourea(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-bis(3-methoxyphenyl)thiourea(6601-00-9)
• EPA Substance Registry System: 1,3-bis(3-methoxyphenyl)thiourea(6601-00-9)

Safety Data

• Hazardous Substances Data: 6601-00-9(Hazardous Substances Data)

Usage

Description

1,3-bis(3-methoxyphenyl)thiourea is a chemical compound belonging to the thiourea class, with the molecular formula C15H16N2O2S. It is known for its white crystalline appearance and a melting point of approximately 218-220°C. This versatile compound has a range of applications in the fields of chemistry, medicine, and industry.

Uses

Used in Organic Synthesis:
1,3-bis(3-methoxyphenyl)thiourea is used as a reagent in the synthesis of various organic compounds, contributing to the development of new chemical entities and materials.
Used in Pharmaceutical Production:
As an intermediate, 1,3-bis(3-methoxyphenyl)thiourea plays a crucial role in the production of pharmaceuticals, aiding in the creation of medications that address a variety of health concerns.
Used in Agrochemicals:
1,3-bis(3-methoxyphenyl)thiourea is also utilized in the agrochemical industry, serving as an intermediate in the development of products designed to enhance crop protection and yield.
Used in Medicinal Research:
1,3-bis(3-methoxyphenyl)thiourea is studied for its potential medicinal properties, such as its anti-inflammatory and anti-tumor effects, which could lead to advancements in the treatment of various diseases and conditions.

Upstream product

• 75-15-0 carbon disulfide 
• 536-90-3 m-Anisidine 
• 56-23-5 tetrachloromethane 

Downstream Products

• 82686-72-4 [4-Isopropyl-3-(3-methoxy-phenyl)-3H-thiazol-(2Z)-ylidene]-(3-methoxy-phenyl)-amine 
• 32826-90-7 3-(3-methoxy-phenyl)-2-(3-methoxy-phenylimino)-thiazolidin-4-one 
• 16460-28-9 N,N'-bis(3-methoxyphenyl)urea 
• 79051-51-7 2-(m-methoxyphenylimino)-3-(m-methoxyphenyl)-4-(m-nitrophenyl)-Δ4-thiazoline 
• 82694-48-2 (3-Methoxy-phenyl)-[3-(3-methoxy-phenyl)-4,5-dimethyl-3H-thiazol-(2Z)-ylidene]-amine 
• 79051-37-9 2-(m-methoxyphenylimino)-3-(m-methoxyphenyl)-4-(p-ethoxyphenyl)-Δ4-thiazoline 
• 82694-31-3 [4-Ethyl-3-(3-methoxy-phenyl)-5-methyl-3H-thiazol-(2Z)-ylidene]-(3-methoxy-phenyl)-amine 
• 79051-22-2 2-(m-methoxyphenylimino)-3-(m-methoxyphenyl)-4-(p-tolyl)-Δ4-thiazoline 
• 82694-65-3 [5-Isopropyl-3-(3-methoxy-phenyl)-4-methyl-3H-thiazol-(2Z)-ylidene]-(3-methoxy-phenyl)-amine 
• 82694-15-3 [5-Ethyl-3-(3-methoxy-phenyl)-4-methyl-3H-thiazol-(2Z)-ylidene]-(3-methoxy-phenyl)-amine 
• 41467-81-6 bis-(3-methoxy-phenyl)-carbodiimide 

Relevant articles and documents

Novel non-peptidic small molecule inhibitors of secreted aspartic protease 2 (SAP2) for the treatment of resistant fungal infections

Targeting secreted aspartic protease 2 (SAP2), a kind of virulence factor, represents a new strategy for antifungal drug discovery. In this report, the first-generation of small molecule SAP2 inhibitors was rationally designed and optimized using a structure-based approach. In particular, inhibitor 23h was highly potent and selective and showed good antifungal potency for the treatment of resistant Candida albicans infections.

Synthesis of thioureas in ionic liquid medium

A highly efficient procedure for the synthesis of symmetrical thioureas by means of simple condensation of primary amines and carbon disulfide in 1-butyl-3-methylimidazolium chloride [BMIM][Cl] as a cheap and commercially available ionic liquid is presented. This procedure works for aromatic and aliphatic primary amines and give high to excellent yields of symmetrical thioureas without need for any catalyst or tedious work-up.