6601-00-9

Usage

Uses

Used in Organic Synthesis:
1,3-bis(3-methoxyphenyl)thiourea is used as a reagent in the synthesis of various organic compounds, contributing to the development of new chemical entities and materials.
Used in Pharmaceutical Production:
As an intermediate, 1,3-bis(3-methoxyphenyl)thiourea plays a crucial role in the production of pharmaceuticals, aiding in the creation of medications that address a variety of health concerns.
Used in Agrochemicals:
1,3-bis(3-methoxyphenyl)thiourea is also utilized in the agrochemical industry, serving as an intermediate in the development of products designed to enhance crop protection and yield.
Used in Medicinal Research:
1,3-bis(3-methoxyphenyl)thiourea is studied for its potential medicinal properties, such as its anti-inflammatory and anti-tumor effects, which could lead to advancements in the treatment of various diseases and conditions.

Upstream product

• 56-23-5 tetrachloromethane 
• 536-90-3 m-Anisidine 
• 75-15-0 carbon disulfide 

Downstream Products

• 41467-81-6 bis-(3-methoxy-phenyl)-carbodiimide 
• 32826-90-7 3-(3-methoxy-phenyl)-2-(3-methoxy-phenylimino)-thiazolidin-4-one 
• 82686-72-4 [4-Isopropyl-3-(3-methoxy-phenyl)-3H-thiazol-(2Z)-ylidene]-(3-methoxy-phenyl)-amine 
• 82694-65-3 [5-Isopropyl-3-(3-methoxy-phenyl)-4-methyl-3H-thiazol-(2Z)-ylidene]-(3-methoxy-phenyl)-amine 
• 79051-22-2 2-(m-methoxyphenylimino)-3-(m-methoxyphenyl)-4-(p-tolyl)-Δ4-thiazoline 
• 82694-48-2 (3-Methoxy-phenyl)-[3-(3-methoxy-phenyl)-4,5-dimethyl-3H-thiazol-(2Z)-ylidene]-amine 
• 79051-51-7 2-(m-methoxyphenylimino)-3-(m-methoxyphenyl)-4-(m-nitrophenyl)-Δ4-thiazoline 
• 79051-37-9 2-(m-methoxyphenylimino)-3-(m-methoxyphenyl)-4-(p-ethoxyphenyl)-Δ4-thiazoline 
• 82694-31-3 [4-Ethyl-3-(3-methoxy-phenyl)-5-methyl-3H-thiazol-(2Z)-ylidene]-(3-methoxy-phenyl)-amine 
• 82694-15-3 [5-Ethyl-3-(3-methoxy-phenyl)-4-methyl-3H-thiazol-(2Z)-ylidene]-(3-methoxy-phenyl)-amine 
• 16460-28-9 N,N'-bis(3-methoxyphenyl)urea 

Relevant academic research and scientific papers

Novel non-peptidic small molecule inhibitors of secreted aspartic protease 2 (SAP2) for the treatment of resistant fungal infections

Targeting secreted aspartic protease 2 (SAP2), a kind of virulence factor, represents a new strategy for antifungal drug discovery. In this report, the first-generation of small molecule SAP2 inhibitors was rationally designed and optimized using a structure-based approach. In particular, inhibitor 23h was highly potent and selective and showed good antifungal potency for the treatment of resistant Candida albicans infections.

Formation of 1,4,2-Dithiazolidines or 1,3-Thiazetidines from 1,1-Dichloro-2-nitroethene and Phenylthiourea Derivatives

A method for preparation of 1,4,2-dithiazolidine or 1,3-thiazetidine heterocycles was developed by reactions of phenylthioureas with 1,1-dichloro-2-nitroethene. The solvent has a significant influence on the type of product formation. 1,4,2-Dithiazolidines were formed in the aprotic solvent chloroform, while in the protic solvent ethanol, 1,3-thiazetidines were the main products.

Synthesis of thioureas in ionic liquid medium

A highly efficient procedure for the synthesis of symmetrical thioureas by means of simple condensation of primary amines and carbon disulfide in 1-butyl-3-methylimidazolium chloride [BMIM][Cl] as a cheap and commercially available ionic liquid is presented. This procedure works for aromatic and aliphatic primary amines and give high to excellent yields of symmetrical thioureas without need for any catalyst or tedious work-up.

Applications of Phase Transfer Catalysis, 26. - Thioureas by Three-Component Reactions of Amines, Carbon Tetrachloride, and Sulfide Ions

The title reactions proceed exothermically in the presence of a phase transfer catalyst.Thiophosgene is an intermediate in this conversion, and its phase transfer catalytic transformation into carbon disulfide and trithiocarbonate can be demonstrated.Perchloromethanethiol/sodium sulfide and a PT catalyst yield thiophosgene too.Activated vicinal dibromides were debrominated by Na2S/catalyst.