16460-28-9

Basic information

• Product Name: Urea, N,N'-bis(3-methoxyphenyl)-
• CAS NO: 16460-28-9
• Molecular Formula: C15H16N2O3
• Molecular Weight: 272.304
• Mol File: 16460-28-9.mol

Chemical Properties

• CAS DataBase Reference: Urea, N,N'-bis(3-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Urea, N,N'-bis(3-methoxyphenyl)-(16460-28-9)
• EPA Substance Registry System: Urea, N,N'-bis(3-methoxyphenyl)-(16460-28-9)

Safety Data

• Hazardous Substances Data: 16460-28-9(Hazardous Substances Data)

Upstream product

• 536-90-3 m-Anisidine 
• 18908-07-1 3-methoxyphenyl isocyanate 
• 124-38-9 carbon dioxide 
• 109-99-9 tetrahydrofuran 
• 41467-81-6 bis-(3-methoxy-phenyl)-carbodiimide 
• 7732-18-5 water 
• 57-13-6 urea 
• 76272-16-7 N-hydroxy-3-(methyloxy)benzenecarboximidoyl chloride 
• 5813-86-5 m-methoxybenzamide 
• 6601-00-9 1,3-bis-(3-methoxy-phenyl)-thiourea 
• 1711-05-3 m-anisoyl chloride 
• 3532-20-5 azido(3-methoxyphenyl)methanone 
• 108708-80-1 ethyl N-(3-methoxyphenyl)carbamate 

Downstream Products

• 3200-36-0 N,N’-bis(3-methoxyphenyl)formamidine 
• 41467-81-6 bis-(3-methoxy-phenyl)-carbodiimide 

Relevant articles and documents

Amide-assisted rearrangement of hydroxyarylformimidoyl chloride to diarylurea

A novel amide-assisted rearrangement reaction of hydroxybenzimidoyl chloride has been established for the efficient synthesis of 1,3-diphenylurea derivatives. A variety of electronically and sterically different 1,3-diphenylurea derivatives can be obtained in good to excellent yields, and a proposed reaction mechanism is also presented.

Method for preparing symmetric urea compound

The invention provides a novel reaction system for synthesizing a symmetric urea compound by taking CO2 as a carbonylation reagent, wherein Lewis base and hydrosilane are used as accelerators and efficiently enable an aromatic/aliphatic primary amine compound to react with normal-pressure CO2 to generate corresponding symmetric urea compounds containing different functional groups under mild conditions (100 DEG C, diglyme). According to the method, normal-pressure CO2 is used as an environmentally-friendly non-toxic carbonylation reagent, and cheap Lewis base and PMHS (industrial silicon waste) are used as accelerators, so that the use of toxic carbonylation reagents, isocyanate, high-pressure CO2, expensive dehydrating agents and precious metals is avoided, purification and separation ofintermediates are not needed, pure products can be obtained only through simple suction filtration and separation after the reaction is finished, and the method is an efficient and novel synthesis method and has high industrial application value.

Sulfated polyborate-catalyzed efficient and expeditious synthesis of (un)symmetrical ureas and benzimidazolones

The excellent catalytic potential of sulfated polyborate is utilized in the synthesis of (un)symmetrical ureas and benzimidazolones by heating amines or substituted OPDA and urea or N-phenylureas under a solvent-free condition at 120 °C is described. The key advantages of the present protocol are phosgene-free, and other hazardous reagents or organic solvent free, high reaction rates and yields, simple workup procedure, and recyclability of the catalyst.

Synthesis of symmetrical ureas by (Diacetoxyiodo)benzene-induced hofmann rearrangement

Amides undergo Hofmann rearrangement by treatment with (diacetoxyiodo) benzene (DAIB) to provide symmetrical ureas in a simple and robust transformation. Georg Thieme Verlag Stuttgart - New York.

C11 Modified Retrosteroids as Progesterone Receptor Modulator Compounds

Retrosteroidal compounds corresponding to formula I, representing progesterone receptor modulators, and their production, and pharmaceutical preparations containing these compounds. These compounds are useful in the treatment of benign gynecological disorders such as endometriosis and uterine fibroids, as well as for female birth control and for hormone replacement therapy.

A simple one-pot procedure for preparing symmetrical diaryllureas from carbon dioxide and aromatic amines

Symmetrical diarylureas can be prepared by purging an aromatic amine with carbon dioxide in the presence of a strong amidine base followed addition of solid commercially available Me3N·SO3. Work up is simply by dilution with water. The procedure is far simpler and safer than traditional methods using phosgene or isocyanates.

NEW ROUTE FOR THE SYNTHESIS OF SYMMETRICAL DIARYLUREA

Several esters of aryl carbamic acid were thermally dissociated into symmetrically diarylurea in high yields.The electronic effect and position of the substitution in the aryl groups as well as the role of the alkyl groups on the thermal reaction are discussed.

A new route for the synthesis of symmetrical diarylureas

Several esters of arylcarbamic acid have been thermally dissociated into symmetrical diarylureas in high yields.The electronic effect and position of substitution in the aryl groups as well as the role of alkyl groups on thermal reaction have been discussed.