6603-24-3

Upstream product

• 108-43-0 3-monochlorophenol 
• 74-85-1 ethene 
• 79-03-8 propionyl chloride 
• 71-43-2 benzene 
• 802294-64-0 propionic acid 

Downstream Products

• 1127-97-5 1-(4-chloro-2-hydroxy-phenyl)-propan-1-one 
• 36871-55-3 4-chloro-2-methoxypropiophenone 
• 2892-21-9 1-<2-Chlor-4-hydroxy-phenyl>-propan-1-on 

Relevant academic research and scientific papers

How much does the hybridization of a carbon atom affect the transmission of the substituent effect on the chemical shift?

1H and 13C NMR spectra of aryl esters of propionic acid, acrylic acid, and propiolic acid were systematically examined to find out the substituent effect on the chemical shift. The values of the chemical shift of the carbonyl carbon showed an inverse correlation with the Hammett ?3 values, and the magnitude of the slope was the largest with the propiolates. The ?± carbons of acrylates and propiolates also showed an inverse correlation with much smaller values of the slopes than those of the carbonyl carbons; but those of the propionates showed absolutely no correlation. However, the ?2 carbons of acrylates and propiolates showed normal correlation with larger values of the slopes. The signs and the magnitudes of the slopes may be understood by the transmission of the substituent electronic effect through bonds as well as through space. The propiolyloxy group also showed a significantly large effect on the 13C chemical shift values of the benzene ring.

Synthesis and activity of 2-methyl-3-aminopropiophenones as centrally acting muscle relaxants

Some novel 2-methyl-3-aminopropiophenones were synthesized and their centrally acting muscle relaxant activities were,evaluated for an inhibitory effect on the flexor reflex in rats. The structure-activity relationships are discussed. In this series 2-methyl-3-pyrrolidino-1-(4-trifluoromethylphenyl)-propan-1-one (28) showed significant centrally acting muscle relaxant activity. In addition, the activities of each enantiomer (28-(S) and (R)) were studied along with their acute toxicities. Compound 28-(R) was found to exhibit more potent activity and weaker acute toxicity than 28-(S). Accordingly, compound 28-(R) (NK433) is under development as a novel centrally acting muscle relaxant.

Certain alkylphenols used to control bacteria

The use of compounds of formula I STR1 wherein X represents chlorine or bromine and n denotes an integer from 1 to 6 for combating harmful microorganisms is disclosed.