660414-48-2

Basic information

• Product Name: Benzoic acid, 4-methoxy-, 7-cyano-2,3-diphenyl-1-indolizinyl ester
• CAS NO: 660414-48-2
• Molecular Formula: C29H20N2O3
• Molecular Weight: 444.489
• Mol File: 660414-48-2.mol

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-methoxy-, 7-cyano-2,3-diphenyl-1-indolizinyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-methoxy-, 7-cyano-2,3-diphenyl-1-indolizinyl ester(660414-48-2)
• EPA Substance Registry System: Benzoic acid, 4-methoxy-, 7-cyano-2,3-diphenyl-1-indolizinyl ester(660414-48-2)

Safety Data

• Hazardous Substances Data: 660414-48-2(Hazardous Substances Data)

Upstream product

• 86203-32-9 7-cyano-2,3-diphenyl-1-indolizinol 
• 100-07-2 4-methoxy-benzoyl chloride 
• 886-38-4 diphenylcyclopropenone 

Relevant articles and documents

Indolizines as novel potent inhibitors of 15-Lipoxygenase

15-Lipoxygenase (15-LO) has been implicated in oxidation of low-density lipoproteins (LDL) and this enzyme may be involved in the development of atherosclerosis. We have examined 1-substituted indolizines as possible inhibitors of 15-LO from soy beans and from rabbit reticulocytes. Most compounds studied were significantly more active as inhibitors of 15-LO from soy beans than quercetin. The indolizines were slightly less potent inhibitors of the mammalian enzyme, but we found good correlation between inhibitory activity against both 15-LO enzymes studied. Several of the compounds were only weak DPPH scavengers and they may therefore be regarded as so-called non antioxidant inhibitors of 15-LO.