6607-66-5Relevant academic research and scientific papers
Thiolation of cycloalkenes C5, C6 by redox-activation of hydrogen sulfide
Shinkar, Elena V.,Kudryavtsev, Daniil A.,Pashchenko, Konstantin P.,Berberova, Nadezhda T.,Okhlobystina, Alexandra V.
, p. 180 - 182 (2017/03/30)
Direct and indirect redox-activation of H2S in the presence of cyclopentene or cyclohexene in MeCN at 25?°C affords the corresponding cycloalkanethiols.
Melamine-(H2SO4)3/melamine-(HNO3)3 instead of H2SO4/HNO3: A safe system for the fast oxidation of thiols and sulfides under solvent-free conditions
Chehardoli, Gholamabbas,Zolfigol, Mohammad Ali
, p. 606 - 612 (2015/11/17)
Melamine reacted with neat sulfuric acid and fuming nitric acid readily to form two new organic solid acids, namely melamine-(H2SO4)3 and melamine-(HNO3)3. Mixture of them acts as a unique powerful system instead of a hazardous H2SO4/HNO3 system for the direct oxidation of thiols. Also, this system can oxidize the sulfides in the presence of a catalytic amount of KBr and few drops of water. This procedure offers advantages such as very low reaction time, simple work-up, excellent yield and matching with some green chemistry protocols.
CERTAIN DIPEPTIDYL PEPTIDASE INHIBITORS
-
Paragraph 0184, (2014/06/11)
Provided are certain dipeptidyl peptidase inhibitors, pharmaceutical compositions thereof, and methods of use therefor.
CERTAIN DIPEPTIDYL PEPTIDASE INHIBITORS
-
Paragraph 0184, (2014/06/11)
Provided are certain dipeptidyl peptidase inhibitors, pharmaceutical compositions thereof, and methods of use therefor.
CERTAIN DIPEPTIDYL PEPTIDASE INHIBITORS
-
Page/Page column 44, (2012/07/14)
Provided are compounds represented by formula (I), their pharmaceutical compositions, and their uses for preparing medicaments as inhibitors of dipepetidyl peptidase-IV enzyme, wherein each substitutuent of formula (I) is defined as the description.
CERTAIN DIPEPTIDYL PEPTIDASE INHIBITORS
-
Page/Page column 43, (2012/07/14)
Provided are certain dipeptidyl peptidase inhibitors, pharmaceutical compositions thereof, and methods of use therefor.
CERTAIN DIPEPTIDYL PEPTIDASE INHIBITORS
-
Page/Page column 43, (2012/07/14)
Provided are certain dipeptidyl peptidase inhibitors, pharmaceutical compositions thereof, and methods of use therefor.
The deoxygenation of sulfoxide mediated by the Ph3P/Lewis acid combination and the application to the kinetic resolution of racemic phosphines using optically active sulfoxide
Kikuchi, Satoshi,Konishi, Hiroyuki,Hashimoto, Yukihiko
, p. 3587 - 3591 (2007/10/03)
It was found that the combination of Ph3P/TiCl4 was an effective promoter for the deoxygenation of sulfoxides and gave the corresponding sulfides in good yield (up to 97%) under mild conditions. This method was applied to the reaction between racemic phosphines and (R)-methyl p-tolyl sulfoxide, and it was found that the kinetic resolution was achieved in moderate selectivities.
Trifluoroacetylation of unsymmetrical ketone acetals. A convenient route to obtain alkyl side chain trifluoromethylated heterocycles
Bonacorso, Helio G.,Martins, Marcos A.P.,Bittencourt, Sandra R.T.,Lourega, Rogerio V.,Zanatta, Nilo,Flores, Alex F.C.
, p. 177 - 182 (2007/10/03)
A convenient method to obtain β-alkyl-β-methoxyvinyl trifluoromethyl ketones [CF3COCHC(OMe)R, where R = Et, n-Pr, i-Pr, i-Bu, t-Bu, -(CH2)2OMe] from the regiospecific acylation of kinetic enol ether generated in situ is reported. The unsymmetrical ketone dimethyl acetals react with trifluoroacetic anhydride in the presence of pyridine using dry chloroform as solvent with a temperature range of 25-60°C. These acetals [R-C(OMe)2Me] are obtained from the reaction of alkyl methyl ketones with trimethyl orthoformate in the presence of p-toluenesulfonic acid as catalyst in pure methanol as solvent. The new acetylated enol ethers proved to be versatile building blocks for the construction of interesting alkyl trifluoromethyl substituted heterocycles. Thus, examples of isoxazoline, pyrazoline, pyrazole and pyrimidinone have been obtained in good yields (62-79%).
