66075-00-1Relevant academic research and scientific papers
Lewis Acid-Catalyzed Nucleophilic Substitutions of Benzylic Alcohols with Sulfamides
Oda, Ryoga,Nakata, Kenya
, p. 295 - 301 (2020/12/11)
Nucleophilic substitutions of benzylic alcohols with sulfamides were achieved using an FeCl3 Lewis acid catalyst in MeNO2. It was necessary to adjust the reaction conditions to obtain efficient yields depending on the stability of the carbocation intermediates. The reaction could easily be performed, and it was revealed that a variety of diarylmethanols and benzylic alcohols were applicable to the reaction, irrespective of the type and position of the substituents. The sulfamide moieties were easily deprotected and converted into amine groups.
Bis-sulfamyl imines: Potent substrates for asymmetric additions of arylboroxines under rhodium catalysis
Crampton, Rosemary,Woodward, Simon,Fox, Martin
supporting information; experimental part, p. 903 - 906 (2011/06/19)
Bis-sulfamyl imines are shown to be potentially ideal substrates for rhodium-catalysed asymmetric additions of arylboron nucleophiles as they show: (i) near perfect enantioselectivities (11 examples, 98-99+% ee), (ii) good to excellent diastereoselectivities (10-32:1 rac:meso), and (iii) high functional group tolerance in removal of the low molecular weight protecting group via mild heating in aqueous pyridine.
A NEW SYNTHESIS OF PRIMARY AMINES FROM DIARYLIDENESULFAMIDES
Davis, Franklin A.,Giangiordano, Mark A.,Starner, William E.
, p. 3957 - 3960 (2007/10/02)
Addition of organometallic reagents to diarylidenesulfamides affords, after hydroylsis, primary amines illustrating the application of sulfamides as amino protecting groups.
