660869-82-9Relevant articles and documents
Discovery of thiophene inhibitors of polo-like kinase
Emmitte, Kyle A.,Andrews, C. Webb,Badiang, Jennifer G.,Davis-Ward, Ronda G.,Dickson, Hamilton D.,Drewry, David H.,Emerson, Holly K.,Epperly, Andrea H.,Hassler, Daniel F.,Knick, Victoria B.,Kuntz, Kevin W.,Lansing, Timothy J.,Linn, James A.,Mook Jr., Robert A.,Nailor, Kristen E.,Salovich, James M.,Spehar, Glenn M.,Cheung, Mui
scheme or table, p. 1018 - 1021 (2009/09/06)
The discovery and development of a series of thiophenes as potent and selective inhibitors of PLK is described. Identification and characterization of 2, a useful in vitro PLK inhibitor tool compound, is also presented.
5-(1H-Benzimidazol-1-yl)-3-alkoxy-2-thiophenecarbonitriles as potent, selective, inhibitors of IKK-ε kinase
Bamborough, Paul,Christopher, John A.,Cutler, Geoffrey J.,Dickson, Marion C.,Mellor, Geoffrey W.,Morey, James V.,Patel, Champa B.,Shewchuk, Lisa M.
, p. 6236 - 6240 (2007/10/03)
The identification and hit-to-lead exploration of a novel, potent and selective series of substituted benzimidazole-thiophene carbonitrile inhibitors of IKK-ε kinase is described. Compound 12e was identified with an IKK-ε enzyme potency of pIC50/sub
BENZIMIDAZOL SUBSTITUTED THIOPENE DERIVATIVES WITH ATCTIVITY ON IKK3
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Page/Page column 31-32, (2008/06/13)
A compound of Formula (I): and compositions and medicaments containing the same, as well as processes for the preparation and use of such compounds, compositions and medicaments. Such benzimidazole derivatives are potentially useful in the treatment of di
THIOPHENE COMPOUNDS
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Page 179, (2008/06/13)
The present invention provides compounds of formula (I): (I) pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.
