916985-23-4Relevant academic research and scientific papers
5-(1H-Benzimidazol-1-yl)-3-alkoxy-2-thiophenecarbonitriles as potent, selective, inhibitors of IKK-ε kinase
Bamborough, Paul,Christopher, John A.,Cutler, Geoffrey J.,Dickson, Marion C.,Mellor, Geoffrey W.,Morey, James V.,Patel, Champa B.,Shewchuk, Lisa M.
, p. 6236 - 6240 (2006)
The identification and hit-to-lead exploration of a novel, potent and selective series of substituted benzimidazole-thiophene carbonitrile inhibitors of IKK-ε kinase is described. Compound 12e was identified with an IKK-ε enzyme potency of pIC50/sub
