6610-36-2

Usage

Uses

Used in Medicinal Chemistry:
4-(4-Chlorobenzyl)-3-thiosemicarbazide is used as a potential compound in medicinal chemistry for its possible antimicrobial, antiviral, and anticancer properties. The presence of a chlorine atom and a benzyl group in its structure may contribute to these biological activities, making it a valuable candidate for further research and development in the pharmaceutical industry.
Used in Chelating Agents:
4-(4-Chlorobenzyl)-3-thiosemicarbazide is used as a potential chelating agent due to the properties of thiosemicarbazides. Its ability to form metal complexes could make it valuable in the development of new coordination compounds for various applications in chemistry and materials science.
Used in Organic Synthesis:
As a derivative of thiosemicarbazide, 4-(4-Chlorobenzyl)-3-thiosemicarbazide is used in organic synthesis for its ability to form various heterocycles and metal complexes. This versatility makes it a useful building block in the synthesis of complex organic molecules and compounds with potential applications in various fields.
Used in Materials Science:
4-(4-Chlorobenzyl)-3-thiosemicarbazide is used in materials science for the development of new coordination compounds. Its potential as a chelating agent and the presence of a chlorine atom and a benzyl group in its structure make it a promising candidate for creating novel materials with unique properties and applications.

InChI:InChI=1/C26H20N4O3S/c1-15-18(25-29-23-21(33-25)11-6-12-27-23)9-5-10-20(15)28-26(34)30-24(31)19-13-16-7-3-4-8-17(16)14-22(19)32-2/h3-14H,1-2H3,(H2,28,30,31,34)

Upstream product

• 104-86-9 4-chlorobenzylamine 
• 75-15-0 carbon disulfide 
• 3694-45-9 4-chlorobenzylisothiocyanate 

Downstream Products

• 34930-27-3 (4-chloro-benzyl)-[1,2,3,4]thiatriazol-5-yl-amine 
• 1298017-06-7 C₂₀H₁₇ClN₄O₂S 

Relevant academic research and scientific papers

Structural revision of the Mcl-1 inhibitor MIM1: synthesis and biological studies on ovarian cancer cells with evaluation of designed analogues

In the area of cancer research, the development of new and potent inhibitors of anti-apoptotic proteins is a very active and promising topic. The small molecule MIM1 has been reported earlier as one of the first selective inhibitors of the anti-apoptotic protein Mcl-1. In the present paper, we first revised the structure of this molecule based on extensive physicochemical analyses. Then we designed and synthesized a focused library of analogues for the corrected structure of MIM1. Next, these molecules were subjected to a panel ofin cellulobiological studies, allowing the identification of dual Bcl-xL/Mcl-1 inhibitors, as well as selective Mcl-1 inhibitors. These results have been complemented by fluorescence polarization assays with the Mcl-1 protein. Preliminary structure-activity relationships were discussed and extensive molecular modelling studies allowed us to propose a rationale for the biological activity of this series of new inhibitors, in particular for the selectivity of inhibition of Mcl-1versusBcl-xL

Carbazole-based semicarbazones and hydrazones as multifunctional anti-Alzheimer agents

With the aim to combat a multi-faceted neurodegenerative Alzheimer’s disease (AD), a series of carbazole-based semicarbazide and hydrazide derivatives were designed, synthesized and assessed for their cholinesterase (ChE) inhibitory, antioxidant and biometal chelating activity. Among them, (E)-2-((9-ethyl-9H-carbazol-3-yl)methylene)-N-(pyridin-2-yl)hydrazinecarbothioamide (62) and (E)-2-((9-ethyl-9H-carbazol-3-yl)methylene)-N-(5-chloropyridin-2-yl)hydrazinecarbothioamide (63) emerged as the premier candidates with good ChE inhibitory activities (IC50 values of 1.37 μM and 1.18 μM for hAChE, IC50 values of 2.69 μM and 3.31 μM for EqBuChE, respectively). All the test compounds displayed excellent antioxidant activity (reduction percentage of DPPH values for compounds (62) and (63) were 85.67% and 84.49%, respectively at 100 μM concentration). Compounds (62) and (63) conferred specific copper ion chelating property in metal chelation study. Molecular docking studies of compounds (62) and (63) indicate strong interactions within the active sites of both the ChE enzymes. Besides that, these compounds also exhibited significant in silico drug-like pharmacokinetic properties. Thus, taken together, they can serve as a starting point in the designing of multifunctional ligands in pursuit of potential anti-AD agents that might further prevent the progression of ADs. Communicated by Ramaswamy H. Sarma.

Synthesis, crystal structure, molecular docking studies and bio-evaluation of some N4-benzyl-substituted isatin-3-thiosemicarbazones as urease and glycation inhibitors

Fifteen N4-benzyl-substituted isatin-3-thiosemicarbazones 5a-o were synthesized and evaluated for their urease and glycation inhibitory potential. Lemna aequinocitalis growth and Artemia salina assays were also done to determine their phytotoxi

Synthesis and in vitro bio-activity evaluation of N4-benzyl substituted 5-chloroisatin- 3-thiosemicarbazones as urease and glycation inhibitors

A series of fifteen N4-benzyl substituted 5-chloroisatin-3-thiosemicarbazones 5a-o were synthesized and screened mainly for their antiurease and antiglycation effects. Lemna aequinocitalis growth and Artemia salina assays were carried out to de

Synthesis, X-ray molecular structure, biological evaluation and molecular docking studies of some N4-benzyl substituted 5-nitroisatin-3-thiosemicarbazones

A series of fifteen N4-benzyl substituted 5-nitroisatin-3-thiosemicarbazones 5a–o was synthesized and evaluated for urease inhibitory, phytotoxic and cytotoxic influences. All the compounds proved to be highly potent inhibitors of the enzyme, s