66116-82-3 Usage
Description
Ethanone, 1-[4-chloro-2-(methylthio)-5-pyrimidinyl]is a chemical compound characterized by its unique molecular structure, which includes a pyrimidine ring, a chlorine atom, a methylthio group, and an ethanone moiety. Ethanone, 1-[4-chloro-2-(methylthio)-5-pyrimidinyl]is recognized for its potential biological activities and is commonly utilized in pharmaceutical and agricultural sectors.
Uses
Used in Pharmaceutical Applications:
Ethanone, 1-[4-chloro-2-(methylthio)-5-pyrimidinyl]is employed as a pharmaceutical agent for the treatment of various diseases, such as cancer and infectious ailments, due to its demonstrated biological activities.
Used in Agricultural Applications:
In the agricultural sector, Ethanone, 1-[4-chloro-2-(methylthio)-5-pyrimidinyl]is used as an antifungal and herbicidal agent, making it a valuable ingredient in the development of agricultural pesticides.
Used in Scientific Research:
Ethanone, 1-[4-chloro-2-(methylthio)-5-pyrimidinyl]-'s synthesis and research on its properties have garnered significant attention in the scientific community, with ongoing studies aimed at exploring its potential applications in diverse fields.
Check Digit Verification of cas no
The CAS Registry Mumber 66116-82-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,1,1 and 6 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 66116-82:
(7*6)+(6*6)+(5*1)+(4*1)+(3*6)+(2*8)+(1*2)=123
123 % 10 = 3
So 66116-82-3 is a valid CAS Registry Number.
66116-82-3Relevant articles and documents
C5-substituted pyrido[2,3-d]pyrimidin-7-ones as highly specific kinase inhibitors targeting the clinical resistance-related EGFRT790M mutant
Xu, Tianfeng,Peng, Ting,Ren, Xiaomei,Zhang, Lianwen,Yu, Lei,Luo, Jinfeng,Zhang, Zhang,Tu, Zhengchao,Tong, Linjiang,Huang, Zhaoru,Lu, Xiaoyun,Geng, Meiyu,Xie, Hua,Ding, Jian,Ding, Ke
, p. 1693 - 1697 (2015/09/21)
The development of specific kinase inhibitors has been a long-standing challenge in chemical biology and drug discovery. We have successfully discovered a series of C5-substituted pyrido[2,3-d]pyrimidin-7-ones as highly specific inhibitors against the clinical resistance-related EGFRT790M mutant. One of the most promising compounds, 9f, tightly binds to the EGFRT790M mutant and strongly inhibits its enzymatic function with an IC50 value of 0.80 nM, and displays an extraordinary target specificity with S(35) and S(10) selectivity scores of 0.005 and 0.000, respectively, in a kinase selectivity profiling study against 456 different kinases at 100 nM. The compound also selectively suppresses the proliferation of EGFRT790M mutated H1975 NSCLC cells with an IC50 value of 2.80 nM, but is significantly less toxic to cells with wild-type EGFR. Compound 9f may serve as a promising lead compound for drug discovery overcoming the acquired resistance of NSCLC patients without adverse toxicities.