66127-01-3Relevant articles and documents
Photobiological activity of Ru(ll) dyads based on (Pyren-1 -yl)ethynyl derivatives of 1, 10-Phenanthroline
Monro, Susan,Scott, John,Chouai, Abdellatif,Lincoln, Richard,Zong, Ruifa,Thummel, Randolph P.,McFarland, Sherri A.
body text, p. 2889 - 2900 (2010/05/15)
Several mononuclear Ru(ll) dyads possessing 1, 10-phenanthrollne-appended pyrenylethynylene llgands were synthesized, characterized, and evaluated for their potential in photobiologlcal applications such as photodynamlc therapy (PDT). These complexes interact with DNA via intercalation and photocleave DNA in vitro at submlcromolar concentrations when irradiated with visible light (λirr ≥ 400 nm). Such properties are remarkably sensitive to the position of the ethynylpyrenyl substituent on the 1, 10-phenanthroline ring, with 3-substitutlon showing the strongest binding under all conditions and causing the most deleterious DNA damage. Both dyads photocleave DNA under hypoxic conditions, and this photoactlvity translates well to cytotoxicity and photocytotoxlcity models using human leukemia cells, where the 5- and 3-substituted dyads show photocytotoxiclty at 5-10μM and 10-20μM, respectively, with minimal, or essentially no, dark toxicity at these concentrations. This lack of dark cytotoxicity at concentrations where significant photoactlvity Is observed emphasizes that agents with strong intercalating units, previously thought to be too toxic for phototherapeutic applications, should not be excluded from the arsenal of potential photochemotherapeutic agents under investigation.
Synthesis and properties of 3,8-bis[4-(9H-carbazol-9-yl)phenyl]-1,10- phenanthroline for phosphorescent OLEDs
Ge, Ziyi,Hayakawa, Teruaki,Ando, Shinji,Ueda, Mitsuru,Akiike, Toshiyuki,Miyamoto, Hidetoshi,Kajita, Toru,Kakimoto, Masa-aki
, p. 262 - 263 (2008/09/20)
A novel bipolar molecule, 3,8-bis[4-(9H-carbazol-9-yl)-phenyl]-1,10- phenanthroline (CZPT) was synthesized and employed as the host in phosphorescent organic light-emitting devices (OLEDs). A maximum luminance of 7000 cd/m 2 was achieved using fac-tris(2-phenylpyridine)iridium (Ir(ppy) 3) as the emitting material. Copyright
Liquid-crystalline phenanthrolines
Bousquet,Bruce
, p. 1769 - 1771 (2007/10/03)
The synthesis and mesomorphism of the first liquid-crystalline phenanthrolines are reported.
Simple One-Step Synthesis of 3-Bromo- and 3,8-Dibromo-1,10-Phenanthroline: Fundamental Building Blocks in the Design of Metal Chelates
Tzalis, Dimitrios,Tor, Yitzhak,Failla, Salvatorre,Siegel, Jay S.
, p. 3489 - 3490 (2007/10/02)
Commercially available 1,10-phenanthroline monohydrochloride monohydrate (1) reacts with bromine to give 3-bromo-1,10-phenanthroline (2) and 3,8-dibromo-1,10-phenanthroline (3) as major products in a one step reaction.